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Lipids in vascular function

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Lipids

Abstract

Physiological and pathological vascular responses depend on the action of numerous intercellular mediators, ranging from hormones to gases like nitric oxide, proteins, and lipids. The last group consists not only of the different types of lipoproteins, but also includes a broad array of other lipophilic signaling molecules such as fatty acids, eicosanoids, phospholipids and their derivatives, sphingolipids and isoprenoids. Due to space limitations, it is impossible to discuss all the vascular effects of lipophilic mediators or compounds. Therefore, we will focus on one of the most important lipid-mediated diseases, atherosclerosis. Lipoproteins and especially their native or oxidized lipid compounds affect vascular function in many different ways, and these effects do not only modulate atherogenesis but are of paramount physiological and pathophysiological importance in other diseases, such as inflammation, tumor metastasis, or normal wound healing.

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Abbreviations

AP-1:

activator protein 1

EET:

epoxy-eicosatrienoic acid

HDL:

high density lipoprotein

HETE:

hydroxy-eciosatetraenoic acids

HMG-CoA:

3-hydroxy-3-methyl-glutaryl CoA

ICAM-1:

intercellular adhesion molecule 1

LDL:

low density lipoproteins

Lp(a):

lipoprotein (a)

LT:

leukotriene

LX:

lipoxin

MAP kinase:

mitogen activated protein kinase

mmLDL:

mildly modified low density lipoprotein

NFκB:

nuclear factor kappa B

NO:

nitric oxide

oxLDL:

oxidized low density lipoprotein

PAF:

platelet-activating factor

PDGF:

platelet-derived growth factor

PG:

prostaglandin

PKA:

protein kinase A

PKC:

protein kinase C

PUFA:

polyunsaturated fatty acids

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Authors and Affiliations

  1. Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Klinikum Innenstadt, University of Munich, Pettenkoferstr. 9, 80336, Munich, Germany

    Alois Sellmayer, Nina Hrboticky & Peter C. Weber

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  1. Alois Sellmayer
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  2. Nina Hrboticky
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  3. Peter C. Weber
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Correspondence to Alois Sellmayer.

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Sellmayer, A., Hrboticky, N. & Weber, P.C. Lipids in vascular function. Lipids 34 (Suppl 1), S13–S18 (1999). https://doi.org/10.1007/BF02562222

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