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Stem cell carcinoma of the colon and rectum

Report of two cases and review of the literature

  • Published:
Diseases of the Colon & Rectum

Abstract

Two cases of highly malignant tumors, one originating in the sigmoid colon and the other in the rectum, are presented. Both tumors showed light microscopic, electron microscopic, and immunohistochemical evidence of multidirectional differentiation. The tumors were composed mainly of undifferentiated cells, but focally merging into areas with adenocarcinomatous and squamous differentiation. Ultrastructurally and histochemically, a predominant endocrine differentiation was present in the undifferentiated areas of the tumors. These two cases lend further support to the recent concept of a pluripotential stem cell in the mucosa of the gastrointestinal tract capable of differentiation in several directions.

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References

  1. Peonim V, Thakerngpol K, Pacharee P, Stitnimankarn T. Adenosquamous carcinoma and carcinoidal differentiation of the colon. Cancer 1983;52:1122–5.

    Article  PubMed  CAS  Google Scholar 

  2. Petrelli M, Tetanco E, Reid JD. Carcinoma of the colon with undifferentiated, carcinoid, and squamous features. Am J Clin Pathol 1981;75:581–4.

    PubMed  CAS  Google Scholar 

  3. Sidhu GS. The endodermal origin of digestive and respiratory tract APUD cells. Am J Pathol 1979;96:5–20.

    PubMed  CAS  Google Scholar 

  4. Mills SE, Shannon AM, Cohen AR. Small-cell undifferentiated carcinoma of the colon. Am J Surg Pathol 1983;7:643–51.

    PubMed  CAS  Google Scholar 

  5. Damjanov I, Amenta PS, Bosman FT. Undifferentiated carcinoma of the colon containing exocrine, neuroendocrine and squamous cells. Virchows Arch [A] 1983;401:57–66.

    Article  CAS  Google Scholar 

  6. Sternberger LA. Enzyme-labeled antibodies. In: Sternberger LA, ed. Immunocytochemistry. New York: John Wiley and Sons, 1979:82–103.

    Google Scholar 

  7. Evans RW. Histological appearances of tumors. 2nd ed. Baltimore: Williams & Wilkins, 1966:1089–130.

    Google Scholar 

  8. Ulich TR, Cheng L, Glover H, Yang K, Lewin KL. A colonic adenocarcinoma with argentaffin cells. Cancer 1983;51:1483–9.

    Article  PubMed  CAS  Google Scholar 

  9. Pearse AG. The diffuse neuroendocrine system and the APUD concept: related “endocrine” peptides in the brain, intestine, pituitary, placenta, and anuran cutaneous glands Med. Biol 1977;55:115–25.

    PubMed  CAS  Google Scholar 

  10. Cox WF, Pierce GB. The endodermal origin of the endocrine cells of an adenocarcinoma of the colon of the rat. Cancer 1982;50: 1530–8.

    Article  PubMed  Google Scholar 

  11. Gould VE, Chejfec G. Neuroendocrine carcinomas of the colon. Am J Surg Pathol 1978;2:31–8.

    Article  PubMed  CAS  Google Scholar 

  12. Ho KJ, Herrera GA, Jones JM, Alexander BA. Small cell carcinoma of the esophagus. Hum Pathol 1984;15:460–8.

    Article  PubMed  CAS  Google Scholar 

  13. Gould VE, Memoli VA, Dardi LE. Multidirectional differentiation in human epithelial cancers. J Submicrosc Cytol 1981;13:97–115.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Pathology, Randers Hospital, Randers, Denmark

    Doris H. B. Palvio M.D., Flemming B. Sørensen M.D. & Mogens Kløve-Mogensen M.D.

  2. the Department of Surgery, Hobro Hospital, Hobro, Denmark

    Doris H. B. Palvio M.D., Flemming B. Sørensen M.D. & Mogens Kløve-Mogensen M.D.

  3. Institute of Pathology, Aalborg Hospital, DK-9000, Aalborg, Denmark

    Doris H. B. Palvio M.D., Flemming B. Sørensen M.D. & Mogens Kløve-Mogensen M.D.

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  1. Doris H. B. Palvio M.D.
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  2. Flemming B. Sørensen M.D.
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  3. Mogens Kløve-Mogensen M.D.
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Palvio, D.H.B., Sørensen, F.B. & Kløve-Mogensen, M. Stem cell carcinoma of the colon and rectum. Dis Colon Rectum 28, 440–445 (1985). https://doi.org/10.1007/BF02560233

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  • DOI: https://doi.org/10.1007/BF02560233

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