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The role of impairment of adrenal mineraloglucocorticoid function in the development of infertility in varicocele patients

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Abstract

The study was aimed at the understanding of pathophysiological mechanisms of the impairment of spermatogenesis in varicocele patients. The crucial role of tension increase in the venous plexus of the spermatic cord in spermatogenesis damage in the testis on the varicocele side and absence of any effect of haemodynamic abnormalities on spermatogenesis in the complementary testis has been determined. Retrograde blood flow through the central vein of the left adrenal gland in varicocele has been evidenced by X-ray examination. The role of this phenomenon in the changes of functional activity of the adrenal gland is discussed. Results of the study of functional status of adrenal glands revealed their tendency to provide hyperactivity in synthesis of mineraloglucocorticoids. Correlation between cortisol level in peripheral blood and percentage of abnormal sperm in ejaculate was shown. This fact supported the idea about the existence of a causal interrelationship between abnormalities in the functional status of adrenal glands and development of infertility in varicocele patients.

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References

  1. Ando, S., Giacchetto, C., Beraldi E., Panno, M. L., Carpino, A., Brancati, C.: Progesterone, 17-OH-progesterone, androstendione and testosterone plasma levels in spermatic venous blood of normal men and varicocele patients.Horm. Metab. Res., 17, 99 (1985).

    PubMed  CAS  Google Scholar 

  2. Artifeksov, S. B., Ryzhakov, Yu. D., Mozhzhukhin, V. B.: On pathogenetic role of the temperature factor in varicocele-associated subfertility (in Russian).Urol. Nefrol. (Moskow), 5, 45 (1986).

    Google Scholar 

  3. Beitins, I. Z., Bayard, F., Kowarski, A., Migeon, C. J.: The effect of ACTH administration of plasma testosterone, dihydrotestosterone and serum LH concentration in normal men.Steroids, 21, 553 (1973).

    Article  PubMed  CAS  Google Scholar 

  4. Charny, C. W., Baum, S.: Varicocele and infertility.JAMA, 204, 75 (1968).

    Article  Google Scholar 

  5. Cohen, M. S., Plaine, L., Brown, J. S.: The role of internal spermatic vein plasma catecholamine determinations in subfertile men with varicocele.Fertil. Steril., 26, 1243 (1975).

    PubMed  CAS  Google Scholar 

  6. Comhaire, F., Vermeulen, A.: Varicocele sterility: cortisol and catecholamines.Fertil. Steril., 25, 88 (1974).

    PubMed  CAS  Google Scholar 

  7. Davidson, H. A.: Varicocele and male subfertility.Br. Med. J., 4875, 1378 (1954).

    Google Scholar 

  8. Doerr, P., Pirke, K. M.: Cortisol-induced suppression of plasma testosterone in normal adult males.J. Clin. Endocrinol. Metab., 43, 622 (1976).

    Article  PubMed  CAS  Google Scholar 

  9. Donohue, R. E., Brown, J. S.: Blood gases pH determination in the internal spermatic veins of subfertile men with varicocele.Fertil. Steril., 20, 365 (1969).

    PubMed  CAS  Google Scholar 

  10. Fjallrant, B., Obranto, O.: Clinical and seminal findings in men with sperm antibodies.Acta Obstet. Gynecol. Scand., 47, 451 (1968).

    Article  Google Scholar 

  11. Fleet, I. R., Laurie, M. S., Noordhuizen-Stassen, E., Stassen, E., Setchell, B. P., Wensing, C. J. G.: The flow of blood from artery to vein in the spermatic cord of the ram with some observations on reactive hyperaemia in the testis and the effect of adenosine and noradrenaline.J. Physiol. (Lond.),332, 44 (1982).

    Google Scholar 

  12. Friedman, S. M., Friedman, C. L., Nakashima, M.: Action of cortisone on cardiovascularrenal effects of desoxycorticosterone acetate.Am. J. Physiol., 163, 319 (1950).

    PubMed  CAS  Google Scholar 

  13. Harrison, R. G.: The adrenal circulation in the rabbit.J. Endocrinol., 15, 64 (1957).

    PubMed  CAS  Google Scholar 

  14. Harrison, R. M., Lewis, R. W., Roberts, J. A.: Pathophysiology of varicocele in nonhuman primates: Long-term seminal and testicular changes.J. Urol., 46, 500 (1986).

    CAS  Google Scholar 

  15. Hinton, B. T., Keefer, D. A.: Localization of3H aldosterone in the rat epididymis.Ann. N. Y. Acad. Sci., 438, 670 (1984).

    Article  Google Scholar 

  16. Howards, S. S.: In: Kaufman J. J. (ed.): Current Urologic Therapy, Saunders, Philadelphia-London-Toronto-Mexico City-Rio de Janeiro-Tokyo-Sydney-Hong Kong 1986.

    Google Scholar 

  17. Kawamura, M., Nakamichi, N., Imagawa, N., Tanaka, Y., Tomita, C., Matsuba, M.: Effect of adrenaline on steroidogenesis in primary cultured bovine adrenocortical cells.Jap. J. Pharmacol., 36, 35 (1984).

    PubMed  CAS  Google Scholar 

  18. Kuhn, J. M., Gay, D., Lemercier, J. P., Pugeat, M., Legrand, A., Wolf, L. W.: Fonction testiculaire au cours de la corticothérapie prolongée.Press Med., 15, 559 (1986)

    CAS  Google Scholar 

  19. Lewis, R. W., Harrison, R. M.: Diagnosis and treatment of varicocele.Clin. Obstet. Gynecol., 25, 501 (1982).

    Article  PubMed  CAS  Google Scholar 

  20. Lopatkin, N. A., Morozov, A. V., Zhitnikova, L. N.: Stenotic Lesion of the Renal Vein. (in Russian). Meditsina, Moscow 1984.

    Google Scholar 

  21. Macleod, J.: Seminal cytology in the presence of varicocele.16, 735 (1965).

    CAS  Google Scholar 

  22. Mancini, R. E., Lavieri, J. C., Muller, F., Andrada, J. A., Saraceni, D. J.: Effect of prednisolone upon normal and pathologic human spermatogenesis.Fertil. Steril., 17, 500 (1966).

    PubMed  CAS  Google Scholar 

  23. Manuel, N., Ricardo, P.: Testicular and epididymal pathology. Thieme, Stuttgart-Stratton, New York 1984.

    Google Scholar 

  24. Nagler, H. M., Li, X.-Z., Lizza, F., Deitch, A., White, R. D.: Varicocele: temporal consideration.J. Urol., 134, 411 (1985).

    PubMed  CAS  Google Scholar 

  25. Netto, N. R.: In: Ralph de Vere White (ed.): Aspects of Male Infertility. Baltimore-London, 1982.

  26. Raboch, J., Starka, L.: Hormonal testicular activity in men with a varicocele.Fertil. Steril. 22, 152 (1971).

    PubMed  CAS  Google Scholar 

  27. Raitsina, S. S., Kurnosov, A. V., Yarovaya, I. M., Gladkov, N. S., Davyidov, A. I., Kurnosova, T. R.: Autoimmune nature of spermatogenesis disorders in varicocele models in rats (in Russian).Biull. Eksp. Biol. Med. 87, 44 (1979).

    Article  PubMed  CAS  Google Scholar 

  28. Sapin, M. R.: Vessels of Adrenal Glands (in Russian). Meditsina, Moscow 1974.

    Google Scholar 

  29. Shafik, A., Bedeir, G. A. M.: Venous tension patterns in cord veins. I. In normal and varicocele individuals.J. Urol., 123, 383 (1980).

    PubMed  CAS  Google Scholar 

  30. Takihara, H., Sakatoku, J., Fujii M., Nasu, T., Cosentino M. J. Cockett, A. T. K.: Significance of testicular size measurement in andrology. I. A new orchiometer and its clinical application.Fertil. Steril., 39, 836 (1983).

    PubMed  CAS  Google Scholar 

  31. Umidon, M., Caffaratti, E.: Ricerche anatomo-chirurgiche ed angiografiche sulle anastomosi artero-venose del funicolo e del testicolo nel varicocele essenziale.Minerva Chir., 19, 200 (1964).

    PubMed  CAS  Google Scholar 

  32. Völter, D.: Die idiopathische Varikozele aus andrologischer Sicht.Fortschr. Med., 90, 683 (1972).

    PubMed  Google Scholar 

  33. Young, D.: The influence of varicocele on human spermatogenesis.Br. J. Urol., 28, 426 (1956).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Urologic and Operative Nephrology Clinic of the Pirogov 2nd Medical Institute, Moscow, USSR

    E. B. Mazo, M. V. Koryakin, Ju. V. Kudryavtsev, L. P. Evseev & A. S. Akopyan

  2. Institute of Urology, Moscow, USSR

    E. B. Mazo, M. V. Koryakin, Ju. V. Kudryavtsev, L. P. Evseev & A. S. Akopyan

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  1. E. B. Mazo
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  2. M. V. Koryakin
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  3. Ju. V. Kudryavtsev
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  4. L. P. Evseev
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  5. A. S. Akopyan
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Mazo, E.B., Koryakin, M.V., Kudryavtsev, J.V. et al. The role of impairment of adrenal mineraloglucocorticoid function in the development of infertility in varicocele patients. International Urology and Nephrology 21, 403–416 (1989). https://doi.org/10.1007/BF02559637

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  • DOI: https://doi.org/10.1007/BF02559637

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