Summary
Experiments have been performed on the canine tibia to investigate whether perturbation of the energy metabolism of bone cells can influence the short-term exchange of bone mineral. Simultaneous injection of three radioactive tracers,125I-albumin,85Sr, and86Rb, into the tibial nutrient artery was followed immediately by measurement of the concentration of these tracers in the venous outflow from the bone for a period of 5 minutes. This procedure was performed before and after the injection of potassium cyanide into the bone. From the measured concentrations, extraction ratios for85Sr and86Rb with respect to125I-albumin were calculated. It was found that net extraction after 5 minutes of85Sr was significantly increased. This result indicates that efflux of ions from exchangeable mineral is dependent to a significant extent on the metabolic activity of bone cells.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Howard JE (1956) Present knowledge of parathyroid function with special emphasis upon its limitations. In: Wolstenholme GE, O'Connor CM (eds) Ciba Foundation Symposium on Bone Structure and Metabolism. Little Brown, Boston
Neuman MW (1969) Blood: bone equilibrium. Calcif Tissue Int 34:117–120
Talmage RV (1969) Calcium homeostasis-calcium transportparathyroid action. The effects of parathyroid hormone on the movement of calcium between bone and fluid. Clin Orthop Rel Res 67:210–224
Neuman WF, Neuman MW (1958) The chemical dynamics of bone mineral. University of Chicago Press, Chicago
Triffitt JT, Terepka AR, Neuman WF (1968) A comparative study of the exchange in vivo of major constituents of bone mineral. Calif Tissue Res 2:165–176
Canas F, Terepka AR, Neuman WF (1969) Potassium and the milieu interieur of bone. Am J Physiol 217:117–120
Pinto MR, Kelly PJ (1984) Age-related changes in bone in the dog: fluid spaces and their potassium content. J Orthop Res 2:2–7
Scarpace PJ, Neuman WF (1976) Blood bone disequilibrium. II. Evidence against the active accumulation of calcium or phosphate into the bone extracellular fluid. Calcif Tissue Res 20:151–158
Neuman WF, Brommage R, Meyers CR (1977) The measurement of Ca++ effluxes from bone. Calcif Tissue Res 24:113–117
Neuman WF, Neuman MW, Myers CR (1979) Blood:bone disequilibrium. III. Linkage between cell energetics and Ca fluxes. Am J Physiol 236:C244-C248
Paradis GR, Bassingthwaighte JB, Kelly PJ (1974) Inhibition of transport of calcium-47 and strontium-85 by lanthanum in canine cortical bone. J Appl Physiol 36:221–225
McCarthy ID, Hughes SPF, Orr JS (1980) An experimental model to study the relationship between blood flow and uptake for bone-seeking radionuclides in normal bone. Clin Phys Physiol Meas 1:135–143
Owen M, Triffitt JT, Melick RA (1973) Albumin in bone. In: Hard tissue growth, repair, and remineralisation. Elsevier-Excerpta Medica-North Holland-Associated Science Publishers, Amsterdam
Sheehan RM, Renkin EM (1972) Capillary, interstitial, and cell membrane barriers to blood-tissue transport of potassium and rubidium in skeletal muscle. Circ Res 30:588–607
McCarthy ID, Hughes SPF (1983) The role of skeletal blood flow in determining the uptake of99mTc-methylene diphosphonate. Calcif Tissue Int 35:508–511
Maltby B, Lemon GJ, Bassingthwaighte JB, Kelly PJ (1982) Exchange of potassium and strontium in adult bone. Am J Physiol 242:H705-H712
Bassingthwaighte JB (1974) A concurrent flow model for extraction during transcapillary exchange. Circ Res 35:483–503
Day JB, Kelly PJ (1979) Volume of distribution of Sr and K in cortical bone of normal, hypoparathyroid, and hyperparathyroid dogs. Fed Proc 38:1186
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McCarthy, I.D., Hughes, S.P.F. Inhibition of bone cell metabolism increases strontium-85 uptake. Calcif Tissue Int 39, 386–389 (1986). https://doi.org/10.1007/BF02555176
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02555176