Abstract
A case is described of familial polyposis of the colon, which combines almost every recorded manifestation of the syndrome of associated tumors; namely, carcinomatous changes in the polyps, osteomas of facial and other bones, periampullary carcinoma, transitional-cell carcinoma of the bladder, adrenal adenoma, intra-abdominal fibrous tumors with bowel obstruction and a remarkable tendency to contain and survive the malignancies.
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Smith T. Three cases of multiple polypi of the lower bowel occurring in one family, with remarks. S Barth Hosp Rep 1887; 23:225–9.
Gardner EJ, Stephens FE. Cancer of the lower digestive tract in a one family group. Am J Hum Genet 1950;2:41–8.
Cabot RC. Case records of the Massachusetts General Hospital, Case No. 21061. N Engl J Med 1935;212:263–7.
Shephard JA. Familial polyposis of the colon with special reference to regression of rectal polyposis after a subtotal colectomy. Br J Surg 1971;58:85–91.
MacDonald JM, Davis WC, Crago HR, Berk AD. Gardner's syndrome and periampullary malignancy. Am J Surg 1967;113:425–30.
Capps WF, Lewis MI, Gazzaniga DA. Carcinoma of the colon, ampulla of Vater, urinary bladder with familial multiple polyposis. Dis Colon Rectum 1968;11:298–305.
Parks TG, Bussey JHR, Lockhart-Mummery HE. Familial polyposis coli associated with extra colonic abnormalities. Gut 1970;11:323–9.
Jones JR, Nance FC. Periampullary malignancy in Gardner's syndrome. Ann Surg 1977;185:565–73.
Lees CD, Hermann RE. Familial polyposis coli associated with bile duct cancer. Am J Surg 1981;141:378–80.
Turcot J, Despres JP, St. Pierre F. Malignant tumors of central nervous system associated with familial polyposis of colon: report of two cases. Dis Colon Rectum 1959;2:465–8.
Camiel MR, Mule JE, Alexander LL, Benninghoff DL. Association of thyroid carcinoma with Gardner's syndrome in siblings. N Engl J Med 1968;278:1056–8.
Smith WG, Kern BB. The nature of the mutation in familial multiple polyposis; papillary carcinoma of the thyroid, brain tumors, and familial multiple polyposis. Dis Colon Rectum 1973;16:264–71.
Collins DC. The frequent association of other body tumors with familial polyposis. Am J Gastroenterol 1959;31:376–81.
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Butson, A.R.C. Familial multiple polyposis coli with multiple associated tumors. Dis Colon Rectum 26, 578–582 (1983). https://doi.org/10.1007/BF02552964
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DOI: https://doi.org/10.1007/BF02552964