Abstract
This review includes the initial experience with NMR imaging of the liver, spleen, and pancreas at the University of California, San Francisco, using a prototype 0.35 Tesla system. This experience shows great promise for detection of hepatic metastases using T1-weighted pulse sequences. T2-weighted pulse sequences appear sensitive for detecting cavernous hemangioma of the liver and may allow tissue specific discrimination of the benign lesion from cancer. NMR is also suitable for evaluating diffuse metabolic alterations and is sensitive and specific for the diagnosis of iron overload. Detection of fatty liver requires use of chemical shift techniques as conventional NMR imaging pulse sequences are relatively insensitive. Motion artifacts and lack of an effective bowel contrast agent limits imaging of the pancreas and retroperitoneum, where CT remains the procedure of choice. The normal spleen has longer T1 and T2 relaxation times than liver or pancreas and NMR has not been successful in diagnosing splenic metastases or lymphoma on a routine basis. We conclude that NMR imaging will be valuable in the diagnosis of focal liver disorders; until fast scan techniques and effective magnetic contrast agents are available for oral and/or intravenous use, other abdominal applications will remain limited.
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Hawkes RC, Holland GN, Moore WS, et al. (1981) Nuclear magnetic resonance (NMR) tomography of the normal abdomen. J Comput Assist Tomogr 5:613
Young IR, Bailes DR, Burl M, et al. (1982) Initial clinical evaluation of a whole body nuclear magnetic resonance tomography. J Comput Assist Tomogr 6:1
Crooks L, Arakawa M, Hoenninger J, et al. (1982) Nuclear magnetic resonance whole-body imager operating at 3.5 kGauss. Radiology 143:169
Margulis AR, Moss AA, Crooks LE, et al. (1983) NMR imaging of tumors of the liver. Semin Roentgenol 18:123
Doyle FH, Pennock JM, Banks LM, et al. (1982) Nuclear magnetic resonance imaging of the liver: Initial experience. AJR 138:193
Smith FN, Mallard JR, Reid A, et al. (1981) Nuclear magnetic imaging in liver disease. Lancet 1:963
Smith FW (1983) Two years' clinical experience with NMR imaging. Appl Radiol 12(3):29
Moss AA, Goldberg HI, Stark DD, et al. (1984) Nuclear magnetic resonance imaging of hepatic tumors. Radiology 150:141–147
Herfkens R, Davis PL, Crooks LE, et al. (1981) Nuclear magnetic resonance imaging of the abnormal live rat and correlation with tissue characteristics. Radiology 144:211
Alfidi RJ, Haaga JR, El Yousef SJ, et al. (1982) Preliminary experimental results in humans and animals with a superconducting whole-body nuclear magnetic resonance scanner. Radiology 143:175
Henkelman RM, Poon PY, Bronskill MJ, Ege GN (1984) Optimized MR image contrast for liver metastases. Presented at the Society of Magnetic Resonance; Third Annual Meeting, New York City, August 16, 1984
Stark DD, Bass NM, Moss AA, et al. (1983) Assessment of experimentally induced liver disease by NMR imaging. Radiology 148:743–751
Stark DD, Goldberg HI, Moss AA, et al. (1984) Nuclear magnetic resonance imaging of chronic liver disease. Radiology 150:149–151
Pykett IL, Rosen BR (1983) Nuclear magnetic resonance: In vivo proton chemical shift imaging. Radiology 149:197–201
Lee JKT, Dixon WT, Ling D, et al. (1984) Fatty infiltration of the liver: Demonstration by proton spectroscopic imaging. Radiology 153:195–201
Stark DD, Moseley M, Bacon BR, et al. (1985) Magnetic resonance imaging and spectroscopy of hepatic iron overload. Radiology 154:137–142
Goldberg HI, Moss AA, Stark DD, et al. (1985) Magnetic resonance imaging of hepatic fibrosis. Radiology 153:737–739
Mallard JR (1983) NMR imaging at Aberdeen: A historical perspective. In: Partain CL, James AE, Rollo FD, et al. (eds) Nuclear magnetic resonance (NMR) imaging, Saunders, Philadelphia, pp 15–41
Straughan K, Spencer DH, Bydder GM (1983) NMR clinical results: Hammersmith. In: Partain CL, James AE, Rollo FD, et al. (eds) Nuclear magnetic resonance (NMR) imaging, Saunders, Philadelphia, pp 195–200
Hollis DP, Saryan LA, Eggleston JC, et al. (1975) Nuclear magnetic resonance studies of cancer. VI. Relationship among spin-lattice relaxation times, growth rate, and water contents of Morris hepatomas. JNCI 54:1469
Kiricuta I-C Jr, Simplaceanu V (1975) Tissue water content and nuclear magnetic resonance in normal and tumor tissues. Cancer Res 13:1164
Smith RW, Reid A, Hutchinson JMS, et al. (1983) Nuclear magnetic resonance imaging of the pancreas. Radiology 142:677
Stark DD, Moss AA, Goldberg HI, et al. (1984) Nuclear magnetic resonance imaging of the pancreas: Normal and pathologic findings. Radiology 150:153–162
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Stark, D.D., Moss, A.A. & Goldberg, H.I. Nuclear magnetic resonance of the liver, spleen, and pancreas. Cardiovasc Intervent Radiol 8, 329–341 (1986). https://doi.org/10.1007/BF02552370
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DOI: https://doi.org/10.1007/BF02552370