Abstract
There has recently been renewed interest in the use of hyperthermia (42.5–44°C) for the management of malignant disease. One method of producing these temperatures is to deliver Nd-YAG laser light via an artificial sapphire probe. This technique has been evaluated on normal rat liver using powers of 1–3W and exposure times of 100–1200s. Discrete areas of hepatic necrosis were produced which healed by the development of an inflammatory response to form fibrotic scars. Thermometry showed that 3W produced a temperature of 42.5°C at 5 mm from the probe and this technique should therefore be capable of heating tumours.
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Sweetland, H.M., Wyman, A. & Rogers, K. Evaluation of the effect on normal liver of interstitial laser hyperthermia using artificial sapphire probes. Laser Med Sci 8, 99–105 (1993). https://doi.org/10.1007/BF02547805
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DOI: https://doi.org/10.1007/BF02547805