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Laser-Induced Interstitial Thermotherapy

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Image-Guided Cancer Therapy

Abstract

Image-guided thermal ablation of hepatic malignancies has been successfully performed with laser applicators. Local control rates after laser ablation of HCC and hepatic metastases as well as 1-, 3-, and 5-year survival rates are now available, and they support a competitive role to other methods of ablative therapy in the management of hepatic malignancies with an acceptably low rate of major complications.

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References

  1. Vogl TJ, Straub R, Eichler K, Mack MG. Laser-induced interstitial thermotherapy (LITT) of liver lesions – technique and application data-clinical data. Percutaneous Tumor Ablation in Medical Radiology, vol. VI. Berlin/Heidelberg: Springer; 2007. p. 139–44.

    Google Scholar 

  2. Bismuth H, Chiche L, Adam R, Castaing D, Diamond T, Dennison A. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg. 1993;218:145–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ramsey WH, Wu GY. Hepatocellular carcinoma: update on diagnosis and treatment. Dig Dis. 1995;13:81–91.

    Article  CAS  PubMed  Google Scholar 

  4. De Cobelli F, Castrucci M, Sironi S, et al. Role of magnetic resonance in the follow-up of hepatocarcinoma treated with percutaneous ethanol injection (PEI) or transarterial chemoembolization (TACE). Radiol-Med-Torino. 1994;88:806–17.

    PubMed  Google Scholar 

  5. Dodd 3rd GD, Soulen MC, Kane RA, et al. Minimally invasive treatment of malignant hepatic tumors: at the threshold of a major breakthrough. Radiographics. 2000;20:9–27.

    Article  PubMed  Google Scholar 

  6. Kawai S, Tani M, Okumura J, Ogawa M, et al. Prospective and randomized clinical trial of lipiodol-transcatheter arterial chemoembolization for treatment of hepatocellular carcinoma: a comparison of epirubicin and doxorubicin (second cooperative study). Semin Oncol. 1997;24:38–45.

    Google Scholar 

  7. Lorenz M, Waldeyer M, Muller HH. Comparison of lipiodol-assisted chemoembolization versus only conservative therapy in patients with nonresectable hepatocellular carcinomas. Z Gastroenterol. 1996;34:205–6.

    CAS  PubMed  Google Scholar 

  8. Amin Z, Lees WR, Bown SG. Hepatocellular carcinoma: CT appearance after percutaneous ethanol ablation therapy. Radiology. 1993;188:882–3.

    Article  CAS  PubMed  Google Scholar 

  9. Bartolozzi C, Lencioni R. Ethanol injection for the treatment of hepatic tumors. Eur Radiol. 1996;6:682–96.

    CAS  PubMed  Google Scholar 

  10. Livraghi T, Lazzaroni S, Vettori C. Percutaneous ethanol injection of small hepatocellular carcinoma. Rays. 1990;15:405–10.

    CAS  PubMed  Google Scholar 

  11. Sato M, Watanabe Y, Tokui K, Kawachi K, Sugata S, Ikezoe J. CT-guided treatment of ultrasonically invisible hepatocellular carcinoma. Am J Gastroenterol. 2000;95:2102–6.

    Article  CAS  PubMed  Google Scholar 

  12. Shiina S, Tagawa K, Unama T, et al. Percutaneous ethanol injection therapy of hepatocellular carcinoma: analysis of 77 patients. AJR. 1990;155:1221–6.

    Article  CAS  PubMed  Google Scholar 

  13. Sironi S, Livraghi T, DelMaschio A. Small hepatocellular carcinoma treated with percutaneous ethanol injection: MR imaging findings. Radiology. 1991;180:333–6.

    Article  CAS  PubMed  Google Scholar 

  14. Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, Solbiati L, Gazelle GS. Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection. Radiology. 1999;210:655–61.

    Article  CAS  PubMed  Google Scholar 

  15. Vogl TJ, Mack MG, Balzer JO, Engelmann K, Straub R, Eichler K, Woitaschek D, Zangos S. Liver metastases: neoadjuvant downsizing with transarterial chemoembolization before laser-induced thermotherapy. Radiology. 2003;229(2):457–64.

    Article  PubMed  Google Scholar 

  16. Knappe V, Mols A. Laser therapy of the lung: biophysical background. Radiologe. 2004;44(7):677–83.

    Article  CAS  PubMed  Google Scholar 

  17. Vogl TJ, Straub R, Lehnert T, Eichler K, Luder-Luhr T, Peters J, Zangos S, Sollner O, Mack M. Percutaneous thermoablation of pulmonary metastases. Experience with the application of laser-induced thermotherapy (LITT) and radiofrequency ablation (RFA), and a literature review. Rofo. 2004;176(11):1658–66.

    Article  CAS  PubMed  Google Scholar 

  18. Mack MG, Eichler K, Zangos S, Lehnert T, Vogl TJ. Long-term results of MR-guided laser ablation (LITT) of liver metastases of breast cancer. J Clin Oncol. 2008;26(15S):1037. May 20 Supplement.

    Article  CAS  Google Scholar 

  19. Mensel B, Weigel C, Heidecke CD, Stier A, Hosten N. Laser-induced thermotherapy (LITT) of tumors of the liver in central location: results and complications. Rofo. 2005;177(9):1267–75.

    Article  CAS  PubMed  Google Scholar 

  20. Vogl TJ, Straub R, Lehnert T, Eichler K, Luder-Luhr T, Peters J, Zangos S, Söllner O, Mack MG. Percutaneous thermoablation of pulmonary metastases. Experience with the application of laser-induced thermotherapy (LITT) and radiofrequency ablation (RFA), and a literature review. RoFo. 2004;176(11):1658–66.

    Article  CAS  PubMed  Google Scholar 

  21. Vogl TJ, Fieguth HG, Eichler K, Straub R, Lehnert T, Zangos S, Mack MG. Laser-induced thermometry of lung metastases and primary lung tumors. Radiologe. 2004;44(7):693–9.

    Article  CAS  PubMed  Google Scholar 

  22. Hosten N, Stier A, Weigel C, Kirsch M, PULs R, Nerger U, Jahn D, Stroszczynski C, Heidecke CD, Speck U. Laser-induced thermometry (LITT) of lung metastases: description of a miniaturized applicator, optimization, and initial treatment of patients [in German]. RoFo. 2003;175:393–400.

    Article  CAS  PubMed  Google Scholar 

  23. Arienti V, Pretolani S, Pacella CM, Magnolfi F, Caspani B, Francica G, Megna AS, Regine R, Sponza M, Antico E, Di Lascio FM. Complications of laser ablation for hepatocellular carcinoma. Radiology. 2008;246(3):947–55.

    Article  PubMed  Google Scholar 

  24. Pacella CM, Francica G, Di Lascio FM, Arienti V, Antico E, Caspani B, Magnolfi F, Megna AS, Pretolani S, Regine R, Sponza M, Stasi R. Long-term outcome of cirrhotic patients with early hepatocellular carcinoma treated with ultrasound-guided percutaneous laser ablation: a retrospective analysis. J Clin Oncol. 2009;27(16):2615–21.

    Article  PubMed  Google Scholar 

  25. Eichler K, Mack MG, Straub R, Engelmann K, Zangos S, Woitaschek D. Vogl TJ [Oligonodular hepatocellular carcinoma (HCC): MR-controlled laser-induced thermotherapy]. Radiologe. 2001;41:915–22.

    Article  CAS  PubMed  Google Scholar 

  26. Mack MG, Eichler K, Zangos S, Lehnert T, Vogl TJ. Long-term results of MR-guided laser ablation (LITT) of liver metastases of breast cancer. J Clin Oncol. 2008; 26, Mo 15S (May 20 Supplement):1037.

    Article  CAS  Google Scholar 

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Correspondence to Thomas J. Vogl .

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Vogl, T.J., Jost, A., Nabil, M., Mack, M.G. (2013). Laser-Induced Interstitial Thermotherapy. In: Dupuy, D., Fong, Y., McMullen, W. (eds) Image-Guided Cancer Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0751-6_36

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  • DOI: https://doi.org/10.1007/978-1-4419-0751-6_36

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-0750-9

  • Online ISBN: 978-1-4419-0751-6

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