Abstract
The inhibitory effect of 2″-O-glycosylisovitexin (2″-O-GIV), isolated from young green barley leaves, on malonaldehyde (MA) formation from lipids was determined by gas chromatography. Two μmol of 2″-O-GIV inhibited MA formation from 0.2 mmol of squalene by almost 100% upon ultraviolet (UV) irradiation. Only 1 μmol of 2″-O-GIV inhibited 90% of MA formation from 0.2 mmol of ethyl linoleate upon UV irradiation. The effective quantities of 2″-O-GIV were much lower than those of either butylated hydroxytoluene or α-tocopherol. When ethyl linoleate, ethyl linolenate and ethyl arachidonate were oxidized by Fenton’s reagent in the presence of 2″-O-GIV or α-tocopherol, both compounds showed similar activity toward MA formation. Both compounds gave maximum inhibition at doses of 0.1–0.3 μmol for ethyl linoleate, 0.1–0.5 μmol for ethyl linolenate and 0.1–0.5 μmol for ethyl arachidonate.
References
Dillard, C.J., and A.L. Tappel,Lipids 8:183 (1973).
Basu, A.K., and L.J. Marnett,Carcinogenesis 4:331 (1983).
Shamberger, R.J., T.L. Andreone and C.E. Willis,J. Natl. Cancer Inst. 53:1771 (1974).
Basu, A.K., S.M. O’Hara, P. Valladier, K. Stone, O. Moles and L.J. Marnett,Chem. Res. Toxicol. 1:53 (1988).
Inagaki, O., N. Shoji and K. Kaneko,Eiyo To Shokuryo 33:309 (1986).
Paik, T.H., T. Hoshino and T. Kaneda, Ibid.85 (1976).
Rice-Evans, C., and P. Hochstein,Biochem. Biophys. Res. Comm. 100:1537 (1981).
Privett, O.S., and R. Cortesi,Lipids 7:780 (1972).
Pratt, D.E.,Autooxidation in Food and Biological Systems, edited by M.G. Simic, and M. Karel, Plenum Press, New York, 1979, pp. 289–293.
Pratt, D.E., and P.M. Birac,J. Food Sci. 44:1720 (1979).
Kitta, K., Y. Hagiwara and T. Shibamoto,J. Agric. Food Chem. 40:1843 (1992).
Ichinose, T., M.G. Miller and T. Shibamoto,Lipids 24:895 (1989).
Dennis, K.J., and T. Shibamoto,Photochem. Photobiol. 49:711 (1989).
Tamura, H., and T. Shibamoto,J. Am. Oil Chem. Soc. 68:941 (1991).
National Cancer Institute,Bioassay of Butylated Hydroxytoluene (BHT) for Possible Carcinogenicity. NCI Carcinogenesis Technical Report Series No. 150, NIH Publication No. 79–1706, Carcinogenesis Testing Program, Bethesda, 1979.
Osawa, T., M. Namiki and S. Kawakishi,Antimutagenesis and Anticarcinogenesis Mechanisms, edited by Y. Kuroda, D.M. Shankel and M.D. Waters, Plenum Press, New York, 1990.
Chamberlain, J., and S.H. Moss,Photochem. Photobiol. 45:625 (1987).
Meffert, H., W. Diezel and N. Sonnichsen,Experientia 32:1397 (1976).
Poli, G., M.U. Dianzani, K.H. Cheeseman, T.F. Slater, J. Lang and H. Esterbauer,Biochem. J. 227:629 (1985).
Author information
Authors and Affiliations
About this article
Cite this article
Nishiyama, T., Hagiwara, Y., Hagiwara, H. et al. Inhibition of malonaldehyde formation from lipids by an isoflavonoid isolated from young green barley leaves. J Am Oil Chem Soc 70, 811–813 (1993). https://doi.org/10.1007/BF02542607
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02542607