Summary
Products of lipid peroxidation (malonaldehyde, Schiff-bases) were detected in human skin. These products were increased after UV-light exposition, on chronically sun-exposed areas as well as with advancing age. Malonaldehyde cross linked epidermal glucose-6-phosphate-dehydrogenase and diminished their activity.
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References
M. A. Pathak andK. Stratton, Arch. Biochem.123, 468 (1968).
B. E. Johnson andF. Daniels, J. Invest. Dermat.53, 85 (1969).
H. Meffert andP. Reich, Dermat. Mschr.155, 948 (1969).
H. Meffert andI. Lohrisch, Dermat. Mschr.157, 338 (1971).
H. Meffert andG. Reichmann, Acta biol. med. germ.28, 667 (1972).
H. Meffert andI. Lohrisch, Dermat. Mschr.157, 793 (1971).
H. Meffert, Ch. Dressler andB. Meffert, Acta biol. med. germ.29, 667 (1972).
B. L. Fletcher, C. J. Dillard andA. L. Tappel, Analyt. Biochem.52, 1 (1973).
E. J. van Scott, J. Invest. Dermat.18 377 (1952).
W. Diezel, H. Meffert andN. Sönnichsen, Dermatologica150, 154 (1975).
A. L. Shapiro, E. Vinuela andJ. V. Maizel, Biochem. biophys. Res. Commun.28, 815 (1967).
R. Hochschild, Expl Geront.6, 153 (1971).
J. Janatova, K. J. Fuller andJ. M. Hunter, J. biol. Chem.243, 3612 (1968).
Biochemica-Information der Boehringer GmbH Mannheim, Januar 1961.
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We wish to acknowledge the support and encourgement of Dr.W. E. Höhne, Institute of Physiological and Biological Chemistry, Humboldt University Berlin.
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Meffert, H., Diezel, W. & Sönnichsen, N. Stable lipid peroxidation products in human skin: detection, ultraviolet light-induced increase, pathogenic importance. Experientia 32, 1397–1398 (1976). https://doi.org/10.1007/BF01937397
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DOI: https://doi.org/10.1007/BF01937397