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Effects of high levels of dietary fats on the growth of azaserine-induced foci in the rat pancreas

  • Papers from the Brian L. Walker Memorial Symposium on Lipids and Cancer Presented at the 76th AOCS Annual Meeting in Philadelphia, Pennsylvania, May 1985
  • Published:
Lipids

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Abstract

Azaserine induced two phenotypically different populations of foci, namely, acidophilic and basophilic foci. The effects of dietary modification during the post-initiation phase of carcinogesis were examined. A diet of 20% (w/w) unsaturated fat (unsat) compared to a 20% saturated fat (sat) diet or a control diet (5% unsaturated fat) increased the number of acidophilic foci, as well as the thymidine labeling index (LI) of their nuclei. While the basophilic foci are carcinogen-induced and at 2.5 mo post-initiation have a similarly high growth rate to the acidophilic foci, this rate is not sustained as indicated by examination of both the LI and mean size of foci at 4 mo post-initiation.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Dartmouth Medical School, O3756, Hanover, NH

    B. D. Roebuck

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  1. B. D. Roebuck
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A preliminary report has been presented as an abstract (2).

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Roebuck, B.D. Effects of high levels of dietary fats on the growth of azaserine-induced foci in the rat pancreas. Lipids 21, 281–284 (1986). https://doi.org/10.1007/BF02536413

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  • DOI: https://doi.org/10.1007/BF02536413

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