Skip to main content
SpringerLink
Log in

A liquid crystalline phase in human intestinal contents during fat digestion

  • Published:
Lipids

Abstract

A viscous, gel-like phase was found in ultracentrifuged human upper intestinal contents collected during rapid fat lipolysis. This “gel” phase was layered in the ultracentrifuge tube between the micellar and oil phase. The gel contained lipids typical of the micellar and not the oil phase. The concentration of these lipids was higher and the ratio of total bile salts to lipids was lower in the gel than in the micellar phase. The gel, unlike the micellar phase, was birefringent between crossed polarizers. These data demonstrate that lipids in this gel phase can form liquid crystals in the gut during fat digestion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mattson, F.H., and Beck, L.W. (1956)J. Biol. Chem. 219, 735–740.

    PubMed  CAS  Google Scholar 

  2. Hofmann, A.F. (1970)Fed. Proc. 29, 1317–1319.

    PubMed  CAS  Google Scholar 

  3. Borgstrom, B. (1957)Acta Chem. Scand. 11, 749–751.

    CAS  Google Scholar 

  4. Hofmann, A.F., and Borgstrom, B. (1962)Fed. Proc. 21, 42–50.

    Google Scholar 

  5. Thompson, G.R., Barrowman, J., Gutierrez, L., and Dowling, R.H. (1971)J. Clin. Invest. 50, 319–323.

    PubMed  CAS  Google Scholar 

  6. Weiss, J.B., and Holt, P.R. (1971)Gastroenterology 60, 730.

    Google Scholar 

  7. Patton, J.S., and Carey, M.C. (1979)Science 204, 145–148.

    Article  PubMed  CAS  Google Scholar 

  8. Stafford, R.J., and Carey, M.C. (1981)Clin. Res. 29, 511A.

    Google Scholar 

  9. Fine, D., Brown, C. and Northfield, T.C. (1985)Gastroenterology 88, 1982.

    Google Scholar 

  10. Weiss, J.B., and Holt, P.R. (1971)J. Clin. Invest. 50, 97a.

    Google Scholar 

  11. Hofmann, A.F., and Borgstrom, B. (1964)J. Clin. Invest. 43, 247–257.

    PubMed  CAS  Google Scholar 

  12. Blankenhorn, D.H., and Ahrens, E.H. Jr. (1955)J. Biol. Chem. 212, 69–81.

    PubMed  CAS  Google Scholar 

  13. Bartlett, G.R. (1959)J. Biol. Chem. 234, 466–468.

    PubMed  CAS  Google Scholar 

  14. Kelly, T.J., Holt, P.R., and Wu, A.L. (1980)Am. J. Clin. Nutr. 33, 1033–1040.

    PubMed  CAS  Google Scholar 

  15. Adams, G.M., and Sallee, T.L. (1971)J. Chromatogr. 54, 136–140.

    Article  PubMed  CAS  Google Scholar 

  16. Admirand, W.H., and Small, D.M. (1968)J. Clin. Invest. 47, 1043–1052.

    PubMed  CAS  Google Scholar 

  17. Miller, K.W., and Small, D.M. (1982)J. Colloid Interface Sci. 98, 466–478.

    Article  Google Scholar 

  18. Simmonds, W.J., Hofmann, A.F., and Theodor, E. (1967)J. Clin. Invest. 46, 874–890.

    PubMed  CAS  Google Scholar 

  19. Porter, H.P., and Saunders, D.R. (1971)Gastroenterology 60, 781–791.

    Google Scholar 

  20. Mansbach, C.M., Cohen, R.S., and Leff, P.B. (1975),J. Clin. Invest. 56, 1186–1191.

    Article  Google Scholar 

  21. Carey, M.C., Small, D.M., and Bliss, C.M. (1983)Annu. Rev. Physiol. 45, 651–677.

    Article  PubMed  CAS  Google Scholar 

  22. Lindstrom, M., Ljusberg-Wahren, H., Larsson, K., and Borgstrom, B. (1981)Lipids 16, 749–754.

    PubMed  CAS  Google Scholar 

  23. Hofmann, A.F., and Small, D.M. (1967)Annu. Rev. Med. 18, 333–376.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gastrointestinal Research Laboratory, St. Luke's Hospital Center, Amsterdam Ave. at 114th St., 10025, New York, NY

    Peter R. Holt, Beatrice M. Fairchild & Jordan Weiss

  2. Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York

    Peter R. Holt, Beatrice M. Fairchild & Jordan Weiss

Authors
  1. Peter R. Holt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Beatrice M. Fairchild
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jordan Weiss
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Holt, P.R., Fairchild, B.M. & Weiss, J. A liquid crystalline phase in human intestinal contents during fat digestion. Lipids 21, 444–446 (1986). https://doi.org/10.1007/BF02536401

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02536401

Keywords

Search

Navigation