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Dietary ether lipid incorporation into tissue plasmalogens of humans and rodents

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Lipids

Abstract

Chronic feeding of 1-O-octadecyl-sn-glycerol (batyl alcohol) to patients suffering from congenital deficiency in tissue ether glycerolipids showed an increase in the plasmalogens content of their erythrocytes. However, nothing is known about the ether lipid content of other tissues in these patients. Feeding 1-O-heptadecyl-sn-glycerol to young rats showed that this uncommon ether lipid was incorporated to a high extent into the plasmalogens of all tissues except brain. Comparative studies with other precursors, such as 3-O-heptadecyl-sn-glycerol, heptadecanol and heptadecanoic acid, indicated a stereospecific incorporation of the dietary 1-O-alkyl-sn-glycerols into tissue plasmalogens without cleavage of the ether bond. Dietary ether lipids were also shown to be transferred from mothers to suckling rats, but not from pregnant rats to fetuses. The implication of these results to possible dietary ether lipid therapy for patients suffering from peroxisomal disorders is discussed.

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Abbreviations

DHAP:

dihydroxyacetone phosphate

DHAPAT:

dihydroxyacetone phosphate acyltransferase

GPC:

glycerophosphocholine

GPE:

glycerophosphoethanolamine

References

  1. Mangold, H.K. (1983) inEther Lipids: Biochemical and Biomedical Aspects (Mangold, H.K., and Paltauf, F., eds.) pp. 231–238. Academic Press, New York.

    Google Scholar 

  2. Bergström, S., and Blomstrand, R. (1956)Acta Physiol. Scand. 38, 166–172.

    PubMed  Google Scholar 

  3. Blomstrand, R., and Ahrens, Jr., E.H. (1959)Proc. Soc. Exp. Biol. Med. 100, 802–805.

    PubMed  CAS  Google Scholar 

  4. Blomstrand, R. (1959)Proc. Soc. Exp. Biol. Med. 102, 662–665.

    PubMed  CAS  Google Scholar 

  5. Paltauf, F. (1971)Biochim. Biophys. Acta 239, 38–46.

    PubMed  CAS  Google Scholar 

  6. Bandi, Z.L., Mangold, H.K., Hølmer, G., and Aaes-Jørgensen, E. (1971)FEBS Lett. 12, 217–220.

    Article  PubMed  CAS  Google Scholar 

  7. Reichwald, I., and Mangold, H.K. (1977)Nutr. Metab. Suppl. 21, 198–201.

    CAS  Google Scholar 

  8. Weber, N. (1985)J. Lipid Res. 26, 1412–1420.

    PubMed  CAS  Google Scholar 

  9. Schutgens, R.B.H., Heymans, H.S.A., Wanders, R.J.A., van den Bosch, H., and Tager, J.M. (1986)Eur. J. Pediatr. 144, 430–444.

    Article  PubMed  CAS  Google Scholar 

  10. Moser, H.W. (1986)J. Pediatr. 108, 89–91.

    Article  PubMed  CAS  Google Scholar 

  11. Wilson, G.N., Holmes, R.D., and Hajra, A.K. (1988)Am. J. Med. Genet. 30, 771–792.

    Article  PubMed  CAS  Google Scholar 

  12. Heymans, H.S.A., Schutgens, R.B.H., Tan, R., and van den Bosch, H., and Borst, P. (1983)Nature 306, 69–70.

    Article  PubMed  CAS  Google Scholar 

  13. Goldfischer, S., Moore, C.L., Johnson, A.B., Spiro, A.J., Valsamis, M.P., Sisniewski, H.K., Ritsch, R.H., Norton, W.T., Rapin, I., and Gartner, L.M. (1973)Science 182, 62–64.

    Article  PubMed  CAS  Google Scholar 

  14. Hajra, A.K., and Bishop, J.E. (1982)Ann. N.Y. Acad. Sci. 386, 170–181.

    PubMed  CAS  Google Scholar 

  15. Datta, N.S., Wilson, G.N., and Hajra, A.K. (1984)N. Engl. J. Med. 311, 1080–1083.

    Article  PubMed  CAS  Google Scholar 

  16. Schutgens, R.B.H., Romeyn, G.J., Wanders, R.J.A., van den Bosch, H., Schrakamp, G., and Heymans, H.S.A. (1984)Biochem. Biophys. Res. Commun. 120, 179–184.

    Article  PubMed  CAS  Google Scholar 

  17. Webber, K.O., Datta, N.S., and Hajra, A.K. (1987)Arch. Biochem. Biophys. 254, 611–620.

    Article  PubMed  CAS  Google Scholar 

  18. Schrakamp, G., Rosenbloom, C.F.P., Schutgens, R.B.H., Wanders, R.J.A., Heymans, H.S.A., Tager, J.M., and van den Bosch, H. (1985)J. Lipid Res. 26, 867–873.

    PubMed  CAS  Google Scholar 

  19. Kelley, R.I., Datta, N.S., Dobyns, W.B., Hajra, A.K., Moser, A.B., Noetzel, M.J., Zackai, E.H., and Moser, H.W. (1986)Am. J. Med. Genet. 23, 869–901.

    Article  PubMed  CAS  Google Scholar 

  20. Poulos, A., Pollard, A.C., Mitchel, J.D., Wise, D., and Mortimer, G. (1984)Arch. Dis. Child. 59, 222–229.

    PubMed  CAS  Google Scholar 

  21. Hajra, A.K., Das, A.K., Webber, K.O., Holmes, R.G., and Wilson, G.N. (1988) inLipid Storage Disorders: Genetic Diseases Affecting Peroxisomal Lipid Biosynthesis (Salvayre, R., Douste-Blasy, L., and Gatt, S., eds.) pp. 369–380, Plenum Publishing Corporation, New York.

    Google Scholar 

  22. Hajra, A.K., Horie, S., and Webber, K.O. (1988) inBiological Membranes: Aberrations in Membrane Structures and Function (Karnovsky, M.L., Leaf, A., and Bolis, L.C., eds.), pp. 99–116, Alan R. Liss, New York.

    Google Scholar 

  23. Schrakamp, G., Schutgens, R.B.H., Wanders, R.J.A., Heymans, H.S.A., Tager, J.M., and van den Bosch, H. (1985)Biochim. Biophys. Acta 833, 170–174.

    PubMed  CAS  Google Scholar 

  24. Roscher, A., Molzer, B., Bernheimer, H., Stockler, S., Mutz, I., and Paltauf, F. (1985)Pediatr. Res. 19, 930–933.

    PubMed  CAS  Google Scholar 

  25. Wilson, G.N., Holmes, R.G., Custer, J., Lipkowitz, J.L., Stover, J., Datta, N.S., and Hajra, A.K. (1986)Am. J. Med. Genet. 24, 69–82.

    Article  PubMed  CAS  Google Scholar 

  26. Wanders, R.J.A., Purvis, Y.R., Heymans, H.S.A., Bakkeren, J.A.J.M., Parmentier, G.G., Eldere, J.V., Eyssen, H., van den Bosch, H., Tager, J.M., and Schutgens, R.B.H. (1986)J. Inher. Metab. Dis. 9, 335–342.

    Article  PubMed  CAS  Google Scholar 

  27. Horrocks, L.A. (1972) inEther Lipids: Chemistry and Biology (Snyder, F., ed.) pp. 177–272, Academic Press, New York.

    Google Scholar 

  28. Snyder, F., and Pfleger, R.C. (1966)Lipids 1, 328–334.

    Article  CAS  PubMed  Google Scholar 

  29. Ahrne, L., Bjorck, L., and Claesson, O. (1982)Ann. Nutr. Metab. 26, 162–170.

    Article  PubMed  CAS  Google Scholar 

  30. Das, A.K., and Hajra, A.K. (1988)FEBS Lett. 227, 187–190.

    Article  PubMed  CAS  Google Scholar 

  31. Blank, M.L., Cress, F.A., Smith, Z.L., and Snyder, F. (1991)Lipids 26, 166–169.

    PubMed  CAS  Google Scholar 

  32. Tietz, A., Lindberge, M., and Kennedy, E.P. (1964)J. Biol. Chem. 239, 4081–4090.

    PubMed  CAS  Google Scholar 

  33. Bishop, J.E., and Hajra, A.K. (1981)J. Biol. Chem. 256, 9542–9550.

    PubMed  CAS  Google Scholar 

  34. Paltauf, F. (1983) inEther Lipids: Biochemical and Biomedical Aspects (Mangold, H.K., and Paltauf, F., eds.) pp. 107–128, Academic Press, New York.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Mental Health Research Institute and Department of Biological Chemistry, University of Michigan, 48104, Ann Arbor, Michigan

    Arun K. Das & Amiya K. Hajra

  2. Department of Pediatrics, University of Michigan, 48104, Ann Arbor, Michigan

    Ronald D. Holmes

  3. Department of Pediatrics, University of Texas, Southwestern Medical Center, 75235, Dallas, Texas

    Golfer N. Wilson

Authors
  1. Arun K. Das
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  2. Ronald D. Holmes
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  3. Golfer N. Wilson
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  4. Amiya K. Hajra
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Das, A.K., Holmes, R.D., Wilson, G.N. et al. Dietary ether lipid incorporation into tissue plasmalogens of humans and rodents. Lipids 27, 401–405 (1992). https://doi.org/10.1007/BF02536379

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  • DOI: https://doi.org/10.1007/BF02536379

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