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Separation of the stereoisomers of racemic fluoroquinolone antibacterial agents on a crown-ether-based chiral HPLC stationary phase

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Summary

A chiral stationary phase derived from (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid has been successfully used for the direct separation of the enantiomers of recemic fluoroquinolines containing a primary amino group being investigated as antibacterial agents. The chromatographic resolution behavior was found to depend on the content and the type of acidic and organic modifiers in the mobile phase and on the column temperature.

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Authors and Affiliations

  1. Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, 609-735, Pusan, Republic of Korea

    M. H. Hyun & S. C. Han

  2. Department of Drug Evaluation, Korea Food and Drug Administration, Eunpyung-Ku, 122-704, Seoul, Republic of Korea

    J. S. Jin

  3. LG Chemical Ltd., Yu-Sung, P.O. Box 61, 305-380, Taejon, Republic of Korea

    W. Lee

Authors
  1. M. H. Hyun
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  2. S. C. Han
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  3. J. S. Jin
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  4. W. Lee
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Hyun, M.H., Han, S.C., Jin, J.S. et al. Separation of the stereoisomers of racemic fluoroquinolone antibacterial agents on a crown-ether-based chiral HPLC stationary phase. Chromatographia 52, 473–476 (2000). https://doi.org/10.1007/BF02535722

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  • DOI: https://doi.org/10.1007/BF02535722

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