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Antitumor activity of SRI 62-834, a cyclic ether analog of ET-18-OCH3

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Lipids

Abstract

SRI 62-834, an analog of the antitumor agent ET-18-OCH3 in which the oxygen atom at carbon atom 2 has been incorporated into a five-membered heterocycle, has been prepared and evaluated as an antitumor agent. The compound exhibited good cytotoxicity in vitro against a variety of tumor cell lines and was as effective as ET-18-OCH3 given orally in the mouse Meth A sarcoma model. SRI 62-834 was shown to be an inhibitor of platelet-derived growth factor (PDGF), possibly at the receptor level, and platelet-activating factor (PAF) at the receptor level.

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Author notes

  1. Mark L. Lee

    Present address: Bristol-Myers Company, 345 Park Ave., 10154, New York, NY

Authors and Affiliations

  1. Max-Planck-Institut fuer Immunobiologie, Freiburg, Federal Republic of Germany

    Paul G. Munder

  2. Sandoz Research Institute, Route 10, 07936, East Hanover, NJ

    William J. Houlihan, Georgina M. Nemecek, Dean A. Handley, Christine M. Winslow, John Happy & Christian Jaeggi

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  1. William J. Houlihan
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  2. Mark L. Lee
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  3. Paul G. Munder
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  4. Georgina M. Nemecek
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  5. Dean A. Handley
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  6. Christine M. Winslow
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Houlihan, W.J., Lee, M.L., Munder, P.G. et al. Antitumor activity of SRI 62-834, a cyclic ether analog of ET-18-OCH3 . Lipids 22, 884–890 (1987). https://doi.org/10.1007/BF02535549

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  • DOI: https://doi.org/10.1007/BF02535549

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