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Lysophosphatidylcholine accumulation in the ischemic canine heart

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Lipids

Abstract

The production of cardiac arrhythmias and the elevation of lysophosphatidylcholine level in the ischemic myocardium have been well-documented in a number of studies. However, the relationship between the production arrhythmias and the elevation of tissue lysophosphatidylcholine level was not reported. In this study, the lysophosphatidylcholine level and the occurrence of cardiac arrhythmias in the ischemic canine heart were monitored. A temporal relationship between the accumulation of lysophosphatidylcholine and the occurrence of arrhythmias was established after five hr of ischemia. A significant elevation of lysophosphatidylcholine was detected at three hr of ischemia without the occurrence of arrhythmias. The results indicate that cardiac arrhythmias did not cause the elevation of lysophosphatidylcholine and if lysophospholipids are causally related to the arrhythmias that a critical level of the lysophospholipid must accumulate in order to elicit electrophysiological alterations.

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Abbreviations

PVC’s:

premature ventricular contractions

References

  1. Elharrar, V., and Zipes, D.G. (1977)Am. J. Physiol. 233, H329-H345.

    PubMed  CAS  Google Scholar 

  2. Wit, A.L., and Rosen, M.R. (1983)Am. Heart J. 106, 829–839.

    Article  PubMed  Google Scholar 

  3. Katz, A.M., and Messineo, F.C. (1981)Circ. Res. 48, 1–16.

    PubMed  CAS  Google Scholar 

  4. Corr, P.B., Gross, R.W., and Sobel, B.E. (1984)Circ. Res. 55, 135–154.

    PubMed  CAS  Google Scholar 

  5. Corr, P.B., Cain, M.E., Witkowski, F.X., Price, D.A., and Sobel, B.E. (1979)Circ. Res. 44, 822–832.

    PubMed  CAS  Google Scholar 

  6. Arnsdorf, M.F., and Sawicki, G.J. (1981)Circ. Res. 49, 16–30.

    PubMed  CAS  Google Scholar 

  7. Man, R.Y.K., and Choy, P.C. (1982)J. Mol. Cell. Cardiol. 14, 173–175.

    Article  PubMed  CAS  Google Scholar 

  8. Man, R.Y.K., and Lederman, C.L. (1985)Pharmacology 31, 11–16.

    Article  PubMed  CAS  Google Scholar 

  9. Man, R.Y.K., Slater, T.L., Pelletier, M.P.J., and Choy, P.C. (1983)Lipids 18, 677–681.

    PubMed  CAS  Google Scholar 

  10. Harris, A.S. (1950)Circulation 1, 1318–1328.

    PubMed  CAS  Google Scholar 

  11. Mock, T., Pelletier, M.P.J., Man, R.Y.K., and Choy, P.C. (1984)Anal. Biochem. 137, 277–281.

    Article  PubMed  CAS  Google Scholar 

  12. Bartlett, G.R. (1958)J. Biol. Chem. 234, 466–468.

    Google Scholar 

  13. Raheja, R.K., Kaur, C., Singh, A., and Bhatia, I.S. (1973)J. Lipid Res. 14, 695–697.

    PubMed  CAS  Google Scholar 

  14. Allain, C.C., Poon, L.S., Chan, C.S.G., Richmond, W., and Fu, P.C. (1974)Clin. Chem. 20, 470–475.

    PubMed  CAS  Google Scholar 

  15. Weltzien, H.U. (1979)Biochim. Biophys. Acta 559, 259–287.

    PubMed  CAS  Google Scholar 

  16. Shaikh, N.A., and Downar, E. (1981)Circ. Res. 49, 316–325.

    PubMed  CAS  Google Scholar 

  17. Wietzek, M., Arthur, G., Man, R.Y.K., and Choy, P.C. (1985)J. Lipid Res. 26, 1166–1169.

    Google Scholar 

  18. Corr, P.B., Snyder, D.W., Lee, B.I., Gross, R.W., Keim, C.R., and Sobel, B.E. (1982)Am. J. Physiol. 243, H187-H195.

    PubMed  CAS  Google Scholar 

  19. Steenbergen, C., and Jennings, R.B. (1984)J. Mol. Cell. Cardiol. 16, 605–621.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics and Department of Biochemistry, Faculty of Medicine, University of Manitoba, R3E OW3, Winnipeg, Manitoba, Canada

    Anne A. A. Kinnaird, Patrick C. Choy & Ricky Y. K. Man

Authors
  1. Anne A. A. Kinnaird
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  2. Patrick C. Choy
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  3. Ricky Y. K. Man
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Kinnaird, A.A.A., Choy, P.C. & Man, R.Y.K. Lysophosphatidylcholine accumulation in the ischemic canine heart. Lipids 23, 32–35 (1988). https://doi.org/10.1007/BF02535301

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  • DOI: https://doi.org/10.1007/BF02535301

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