Skip to main content
SpringerLink
Log in

Tissue phospholipid fatty acid composition in the diabetic rat

  • Communications
  • Published:
Lipids

Abstract

Tissue phospholipid fatty acid compositions in streptozotocin-induced diabetic rats were studied. The major changes in liver, plasma, erythrocyte and heart were increased proportions of linoleic and dihomo-γ-linolenic acids and a decreased proportion of aracchidonic acid. The latter was not significantly changed in phospholipids of kidney, adrenal gland and testis. Skin fatty acids in diabetic rats showed an increase in the proportion of arachidonic acid and a reduction in the proportion of linoleic acid. The fatty acid desaturating activity in diabetes may be regulated differently in different tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Faas, F.H., and Carter, W.J. (1980) Lipids 15, 953–961.

    Article  CAS  Google Scholar 

  2. Faas, F.H., and Carter, W.J. (1983) Lipids 28, 339–342.

    Google Scholar 

  3. Mercuri, O., Peluffo, R.O., and Brenner, R.R. (1966) Biochim. Biophys. Acta 116, 409–411.

    PubMed  CAS  Google Scholar 

  4. Brenner, R.R. (1974) Mol. Cell Biochem. 3, 41–52.

    Article  PubMed  CAS  Google Scholar 

  5. Friedman, N., Gellhorn A., and Benjamin, W. (1966) Israel J. Med. Sci. 2, 677–682.

    Google Scholar 

  6. Poisson, J.P., Lemarchal, P., Blond, J.P., Lecerf, J., and Mendy, F. (1978) Diabetes Metab. 4, 39–45.

    CAS  Google Scholar 

  7. Brenner, R.R., Peluffo, P.O., Mercuri, O., and Resterlli, M.A. (1968) Am. J. Physiol. 215, 63–70.

    PubMed  CAS  Google Scholar 

  8. Clark, D.L., Hamel, F.G., and Queener, S.F. (1983), Lipids 18, 696–705.

    PubMed  CAS  Google Scholar 

  9. Holman, R.T., Johnson, S.B., Gerrard, J.M., Mauer, S.M., Kupcho-Sandberg, S., and Brown, D.M. (1983) Proc. Natl. Acad. Sci. USA 80, 2375–2379.

    Article  PubMed  CAS  Google Scholar 

  10. Huang, Y.S., Martineau, A., Falardeau, P., and Davignon, J. (1983) Lipids 18, 412–422.

    PubMed  CAS  Google Scholar 

  11. Skipski, V.P., Peterson, R.F., and Barclay, M. (1964) Biochem. J. 90, 374–378.

    PubMed  CAS  Google Scholar 

  12. Morrison, W.R., and Smith, L.M. (1964) J. Lipid Rds. 5, 600–608.

    CAS  Google Scholar 

  13. Manku, M.S., Horrobin, D.F., Huang, Y.S., and Morse, N. (1983) Lipids 18, 906–908.

    PubMed  CAS  Google Scholar 

  14. Brenner, R.R. (1971) Lipids 6, 567–575.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Efamol Research Institute, P.O. Box 818, B4N 4H8, Kentville, Nova Scotia, Canada

    Y. S. Huang, D. F. Horrobin, M. S. Manku, J. Mitchell & M. A. Ryan

Authors
  1. Y. S. Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. F. Horrobin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. S. Manku
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Mitchell
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. A. Ryan
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Huang, Y.S., Horrobin, D.F., Manku, M.S. et al. Tissue phospholipid fatty acid composition in the diabetic rat. Lipids 19, 367–370 (1984). https://doi.org/10.1007/BF02534790

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02534790

Keywords

Search

Navigation