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Suppression of cholesterogenesis by plant constituents: Review of Wisconsin contributions to NC-167

  • Symposium Papers from the Symposium on Dietary Factors Affecting Lipid Metabolism Presented at the 74th AOCS Annual Meeting in Philadelphia, Pennsylvania, May 1983
  • Published:
Lipids

Abstract

In animals, non-sterol metabolites of the mevalonate pathway act independently from receptor-mediated cholesterol uptake in the multivalent feedback regulation of mevalonate biosynthesis. Studies leading to the isolation and characterization of plant-borne suppressors of mevalonate biosynthesis are reviewed. We propose that one cardio-protective component of the vegetarian diet consists of a variety of non-sterol, post-mevalonate metabolites. These products of plant branches of the mevalonate pathway, discarded as animals evolved, continue to influence animal sterol metabolism. It is through this action, we propose, that the cholesterol-suppressive action of plant materials is expressed.

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Author information

Authors and Affiliations

  1. Cereal Crops Research Unit, 501 North Walnut St., 53705, Madison, WI

    A. A. Qureshi, W. C. Burger & D. M. Petterson

  2. Department of Agronomy, University of Wisconsin, 53706, Madison, WI

    C. Elson

  3. Department of Nutritional Sciences, University of Wisconsin, 53706, Madison, WI

    C. Elson

Authors
  1. A. A. Qureshi
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  2. W. C. Burger
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  3. D. M. Petterson
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  4. C. Elson
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Qureshi, A.A., Burger, W.C., Petterson, D.M. et al. Suppression of cholesterogenesis by plant constituents: Review of Wisconsin contributions to NC-167. Lipids 20, 817–824 (1985). https://doi.org/10.1007/BF02534407

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  • DOI: https://doi.org/10.1007/BF02534407

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