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1-Acyl-2-acetyl-sn-glycero-3-phosphocholine from stimulated human polymorphonuclear leukocytes

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Lipids

Abstract

1-Acyl-2-acetyl-sn-glycero-3-phosphocholine (1-acyl-2-acetyl GPC) was found in the fraction of platelet-activating factor obtained from stimulated human polymorphonuclear leukocytes (PMN). The amount of 1-acyl-2-acetyl GPC obtained from 1×107 PMN stimulated with ionophore A23187 at 37 C for 15 min ranged from 8 to 56 pmol (32±10 pmol, mean±standard error; n=4). The main species was 16∶0 palmitoyl (17±5 pmol), followed by 18∶0 stearoyl (8±3 pmol) and 18∶1 oleoyl (7±3 pmol).

Although the physiological significance is unknown, 1-acyl-2-acetyl GPC was always detected when 1-alkyl-2-acetyl GPC was detected.

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References

  1. Satouchi, K., Oda, M., Yasunaga, K., and Saito, K. (1983)J. Biochem. 94, 2067–2070.

    PubMed  CAS  Google Scholar 

  2. Clay, J.M., Murphy, R.C., Andres, J.L., Lynch, J.M., and Henson, P.M. (1984)Biochem. Biophys. Res. Commun. 121, 815–825.

    Article  PubMed  CAS  Google Scholar 

  3. Pinckard, R.N., Jackson, E.M., Hoppens, C., Weintraub, S.T., Ludwig, J.C., McManus, L.M., and Mott, G.E. (1984)Biochem. Biophys. Res. Commun. 122, 325–332.

    Article  PubMed  CAS  Google Scholar 

  4. Satouchi, K., Oda, M., Yasunaga, K., and Saito, K. (1985)Biochem. Biophys. Res. Commun. 128, 1409–1417.

    Article  PubMed  CAS  Google Scholar 

  5. Blank, M.L., Lee, T-c., Fitzgerald, V., and Snyder, F. (1981)J. Biol. Chem. 256, 175–178.

    PubMed  CAS  Google Scholar 

  6. Blank, M.L., Hall, M.H., Cress, E.A., and Snyder, F. (1983)Biochem. Biophys. Res. Commun. 113, 666–671.

    Article  PubMed  CAS  Google Scholar 

  7. Ludwig, J.C., Hoppens, C.L., McManus, L.M., Mott, G.E., and Pinckard, R.N. (1985)Arch. Biochem. Biophys. 241, 337–347.

    Article  PubMed  CAS  Google Scholar 

  8. Oda, M., Satouchi, K., Yasunaga, K., and Saito, K. (1985)J. Immunol. 134, 1090–1093.

    PubMed  CAS  Google Scholar 

  9. Oda, K., Satouchi, K., Yasunaga, K., and Saito, K. (1985),J. Lipid Res. 26, 1294–1299.

    PubMed  CAS  Google Scholar 

  10. Pinckard, R.N., Farr, R.S., and Hanahan, D.J. (1979)J. Immunol. 123, 1847–1857.

    PubMed  CAS  Google Scholar 

  11. Bligh, E.G., and Dyer, W.J. (1959)Can. J. Biochem. Physiol. 37, 911–917.

    PubMed  CAS  Google Scholar 

  12. Jouvin-Marche, E., Ninio, E., Beaurain, G., Tence, M., Niaudet, P., and Benveniste, J. (1984)J. Immunol. 133, 892–898.

    PubMed  CAS  Google Scholar 

  13. Mueller, H.W., O'Flaherty, J.T., and Wykle, R.L. (1984)J. Biol. Chem. 259, 14554–14559.

    PubMed  CAS  Google Scholar 

  14. Weintraub, S.T., Ludwig, J.C., Mott, G.E., McManus, L.M., Lear, C., Pinckard, R.N. (1985)Biochem. Biophys. Res. Commun. 129, 868–876.

    Article  PubMed  CAS  Google Scholar 

  15. Ramesha, C.S., and Pickett, W.C. (1986)J. Biol. Chem. 261, 7592–7595.

    PubMed  CAS  Google Scholar 

  16. Ramesha, C.S., and Pickett, W.C. (1986)Biomed. Environ. Mass Spectrom. 13, 107–111.

    Article  PubMed  CAS  Google Scholar 

  17. McManus, L.M., Hanahan, D.J., and Pinckard, R.N. (1981)J. Clin. Invest. 67, 903–906.

    Article  PubMed  CAS  Google Scholar 

  18. Demopoulos, C.A., Pinckard, R.N., and Hanahan, D.J. (1979)J. Biol. Chem. 254, 9355–9358.

    PubMed  CAS  Google Scholar 

  19. Lynch, J.M., and Henson, P.M. (1986)J. Immunol. 137, 2653–2661.

    PubMed  CAS  Google Scholar 

  20. Ludwig, J.C., McManus, L.M., Clark, P.O., Hanahan, D.J., and Pinckard, R.N. (1984)Arch. Biochem. Biophys. 232, 102–110.

    Article  PubMed  CAS  Google Scholar 

  21. Lynch, J.M., and Henson, P.M. (1985)Fed. Proc. 44, 1272.

    Google Scholar 

  22. Hanahan, D.J. (1986)Ann. Rev. Biochem. 55, 483–509.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Chemistry, Kansai Medical School, Moriguchi, 570, Osaka, Japan

    Kiyoshi Satouchi & Kunihiko Saito

  2. The First Department of Internal Medicine, Kansai Medical School, Moriguchi, 570, Osaka, Japan

    Makoto Oda

Authors
  1. Kiyoshi Satouchi
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  2. Makoto Oda
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  3. Kunihiko Saito
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Satouchi, K., Oda, M. & Saito, K. 1-Acyl-2-acetyl-sn-glycero-3-phosphocholine from stimulated human polymorphonuclear leukocytes. Lipids 22, 285–287 (1987). https://doi.org/10.1007/BF02533994

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  • DOI: https://doi.org/10.1007/BF02533994

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