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Enteral absorption in man of eicosapentaenoic acid in different chemical forms

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Lipids

Abstract

After administering the equivalent of 1 g of eicosapentaenoic acid (EPA) in four different chemical forms, the kinetics of EPA incorporation into plasma triglycerides (TG) were compared by gas liquid chromatography on a capillary column following separation of the lipid fraction by thin layer chromatography.

EPA incorporation into plasma TG was markedly smaller and later when EPA was administered as an ethyl ester rather than as EPA free fatty acid, EPA arginine salt or 1,3-dioctanoyl-2-eicosapentaenoyl glycerol (2-EPA). Our results and the data in the literature are compatible with the hypothesis that 2-EPA is absorbed with minimum hydrolysis and escapes random distribution between the other positions of the glycerol molecule during the absorption process.

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Abbreviations

PUFA:

polyunsaturated fatty acids

AA:

arachidonic acid

EPA:

eicosapentaenoic acid

2-EPA:

1,3-dioctanoyldonic acid

EPA:

eicosapentaenoic acid

2-EPA:

1,3-dioctanoyl-2-eicosapentaenoyl glycerol

EP:

eicosapentaenoate

TG:

triglyceride

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Authors and Affiliations

  1. Laboratoire de Biochimie A, Institut de Biologie, Bd Henri IV, 34000, Montpellier, France

    S. El Boustani, B. Descomps & A. Crastes de Paulet

  2. Service des Maladies Métaboliques, Hôpital Lapeyronie, Montpellier, France

    C. Colette & L. Monnier

  3. Laboratoires SOPHARGA, Puteaux, France

    F. Mendy

Authors
  1. S. El Boustani
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  2. C. Colette
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  3. L. Monnier
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  4. B. Descomps
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  5. A. Crastes de Paulet
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  6. F. Mendy
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Boustani, S.E., Colette, C., Monnier, L. et al. Enteral absorption in man of eicosapentaenoic acid in different chemical forms. Lipids 22, 711–714 (1987). https://doi.org/10.1007/BF02533970

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  • DOI: https://doi.org/10.1007/BF02533970

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