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Effect of dietary fats on pentobarbitone-induced sleeping times and hepatic microsomal cytochrome P-450 in rats

  • Published:
Lipids

Abstract

Female Wistar-derived rats were fed diets containing either sunflowerseed oil or tallow for 4 weeks. Rats fed the sunflowerseed oil diet had longer pentobarbitone-induced sleeping times and lower concentrations of hepatic microsomal cytochrome P-450 than rats fed the tallow diet. The addition of pentobarbitone to the drinking water of rats caused approximately 2-fold increases in the concentrations of hepatic microsomal cytochrome P-450 but did not alter the relative effect of the diets.

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Authors and Affiliations

  1. Department of Experimental Pathology, John Curtin School of Medical Research, The Australian National University, PO Box 334, 2601, Canberra City, ACT, Australia

    G. J. Hopkins & C. E. West

Authors
  1. G. J. Hopkins
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  2. C. E. West
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Hopkins, G.J., West, C.E. Effect of dietary fats on pentobarbitone-induced sleeping times and hepatic microsomal cytochrome P-450 in rats. Lipids 11, 736–740 (1976). https://doi.org/10.1007/BF02533047

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  • DOI: https://doi.org/10.1007/BF02533047

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