Abstract
The common bile duct was obstructed in 17 dogs. Reciprocal changes were noted for the plasma and biliary lipid concentrations of each after obstruction. As the plasma lecithin and free cholesterol concentrations increased, the biliary lipid concentrations declined. After biliary obstruction the reflux of biliary lecithin into the plasma of these animals was demonstrated with both labeled and unlabeled lecithin. The plasma lipid abnormalities seen after acute biliary obstruction were closely simulated by the reflux of lecithin alone from the biliary tree. The isolated reflux of biliary tract taurocholate produced a distinct lowering of plasma phospholipid and cholesterol concentrations, quite different from the plasma lipid alteration noted with acute biliary obstruction. Similar to observations in human obstruction, some of the plasma lipid was in mesophase form after these animals were obstructed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Fredrickson, D.S., A.V. Loud and B.T. Hinkelman, J. Exp. Med. 99:43 (1954).
Russ, E.M., J. Raymunt and D.P. Barr, J. Clin. Invest. 35:133 (1956).
Ahrens, E.H., Jr., and H.G. Kunkel, Ibid. 28:1565 (1949).
Hamilton, R.L., R.J. Havel and J.P. Kane, Science 172:475 (1971).
Quarfordt, S.H., H. Oelschlaeger and W.R. Krigbaum, J. Clin. Invest. 51:1979 (1972).
Howell, J.I., J.A. Lucy, and R.C. Pirola, Biochim. Biophys. Acta 210:1 (1970).
Forte, T., K.R. Norum and J.A. Glomset, J. Clin. Invest. 50:1141 (1971).
Friedman, M., and S. Byers, Amer. J. Physiol. 188:337 (1957).
Byers, S.O., and M. Friedman, Ibid., 168:138 (1952).
Makino, I., S. Nakagawa and K. Mashimo, Gastroenterology 56:1033 (1969).
Havel, R.J., H.A. Eder and J.H. Bragdon, J. Clin. Invest. 34:1345 (1955).
Delalla, O., and J.W. Gofman, “Methods of Biochemical Analysis,” Edited by D. Glich, Interscience Publishers, New York, 1954, p. 1.
Shackman, H.K., “Ultracentrifuge in Biochemistry,” Third edition, Academic Press, New York, 1959, p. 10.
Folch, J., M. Lees and G.H. Sloane-Stanley, J. Biol. Chem. 226:497 (1957).
Weiner, I.M., J.E. Glasser and L. Lack, Amer. J. Physiol. 207:964 (1964).
Bragdon, J.H., and A.K. Karmen, J. Lipid Res. 2:400 (1961).
Irwin, J.L., C.G. Johnston and J. Kopala, J. Biol. Chem. 153:439 (1944).
Sandberg, D.H., J. Sjövall and K. Sjövall, J. Lipid Res. 6:182 (1965).
Ames, B.N., and D.T. Dubin, J. Biol. Chem. 235:769 (1960).
Abell, L.L., B.B. Levy and B.B. Brodie, Ibid. 195:357 (1952).
Lowry, O.H., N.J. Rosebrough and A.L. Farr, Ibid. 193:265 (1951).
Weber, K., and M. Osborn, Ibid. 244:4406 (1969).
Hanahan, D.J., M.B. Turner and M.E. Jayko, Ibid. 192:623 (1951).
Alexander, L.E., “X-Ray Diffraction Methods in Polymer Science,” Wiley, New York, 1969.
Reihart, O.F., and H.W. Reihart, “Canine Medicine,” First edition, Edited by E.J. Catcott, Illinois. American Veterinary Publications Inc. Illinois, 1968, p. 341.
Wilkins, M.H., A.E. Blaurock and D.M. Engelman, Nature (New Biol.) 230:72 (1971).
Byers, S.O., and M. Friedman, Lipids 4:123 (1969).
Byers, S.O., M. Friedman and T. Sugiyama, J. Biol. Chem. 237:3375 (1962).
Weis, H.J., and J.M. Dietschy, J. Clin. Invest. 48:2398 (1969).
Author information
Authors and Affiliations
About this article
Cite this article
Quarfordt, S.H., Oelschlaeger, H., Krigbaum, W.R. et al. Effect of biliary obstruction on canine plasma and biliary lipids. Lipids 8, 522–530 (1973). https://doi.org/10.1007/BF02531988
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02531988