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Genetics of pentose-phosphate pathway enzymes ofEscherichia coli K-12

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Abstract

The pentose-phosphate pathway ofEscherichia coli K-12, in addition to its role as a route for the breakdown of sugars such as glucose or pentoses, provides the cell with intermediates for the anabolism of amino acids, vitamins, nucleotides, and cell wall constituents. Through its oxidative branch, it is a major source of NADPH. The expression of the gene for NADP-dependent 6-phospho-gluconate dehydrogenase (gnd) is regulated by the growth rate inE. coli. The recently identified gene for ribulose-5-phosphate 3-epimerase (rpe) is part of a large operon that comprises among others genes for the biosynthesis of aromatic amino acids. In recent years, genes for all enzymes of the pathway have been cloned and sequenced. Isoenzymes have been found for transketolase (genestktA andtktB), ribose-5-phosphate isomerase (rpiA andrpiB) and transaldolase (talA andtalB).

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  1. Institut für Biotechnologie 1, Forschungszentrum Jülich GmbH, Postfach 1913, D-52425, Jülich

    Georg A. Sprenger

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Sprenger, G.A. Genetics of pentose-phosphate pathway enzymes ofEscherichia coli K-12. Arch. Microbiol. 164, 324–330 (1995). https://doi.org/10.1007/BF02529978

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  • DOI: https://doi.org/10.1007/BF02529978

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