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N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage

  • Cellular Engineering-Technical Note
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Abstract

Bone morphogenetic protein (BMP), associated with N,N-dicarboxymethyl chitosan, is used to induce or facilitate the repair of articular cartilage lesions. This association is intended for the synergistic potentiation of the respective biological effects. Data show that BMP-7 enhances the in vivo proliferation of cells with chondrocytes phenotype in the articular environment, leading to partial healing of the articular surface of the lesions. N,N-dicarboxymethyl chitosan is found to be useful as a molecular carrier or drug delivery agent.

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Authors and Affiliations

  1. Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona, Via Tronto 10/A, 60020, Ancona, Italy

    M. Mattioli-Belmonte, A. De Benedittis & G. Biagini

  2. Orthopedic Clinic, University of Ancona, Italy

    A. Gigante, R. Politano, N. Specchia & F. Greco

  3. Institute of Biochemistry, University of Ancona, Italy

    R. A. A. Muzzarelli

  4. Centre for Innovative Biomaterials, University of Ancona, Italy

    M. Mattioli-Belmonte, A. Gigante, R. A. A. Muzzarelli, A. De Benedittis, N. Specchia, G. Biagini & F. Greco

  5. Department of General Medicine, University of Bologna, Italy

    A. Buffa

Authors
  1. M. Mattioli-Belmonte
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  2. A. Gigante
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  3. R. A. A. Muzzarelli
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  4. R. Politano
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  5. A. De Benedittis
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  6. N. Specchia
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  7. A. Buffa
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  8. G. Biagini
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  9. F. Greco
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Correspondence to M. Mattioli-Belmonte.

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Mattioli-Belmonte, M., Gigante, A., Muzzarelli, R.A.A. et al. N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage. Med. Biol. Eng. Comput. 37, 130–134 (1999). https://doi.org/10.1007/BF02513279

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  • DOI: https://doi.org/10.1007/BF02513279

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