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Preliminary studies of supercritical-fluid chromatography on porous graphitic carbon with methylated cyclodextrin as chiral selector

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Summary

Dimethylated-β-cyclodextrins dynamically adsorbed on porous graphitic carbon have been used as chiral selectors in chiral supercritical-(or subcritical-) fluid chromatography. The kinetics of adsorption and desorption were studied with CO2-methanol+dimethylated-β-cyclodextrins and CO2-methanol as mobile phases. The system was proved to be stable and reproducible and to afford rapid enantiomer separations especially when performed with 95:5 CO2-methanol+dimethylated-β-cyclodextrin as mobile phase. The versatility of the chiral system enabled the use of a variety of chiral selectors. It was found that enantiomer separation can vary largely as a function of the composition of commercial dimethylated-β-cyclodextrin mixture.

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Authors and Affiliations

  1. Institut de Chimie Organique et Analytique, UPRESA CNRS 6005, Université d'Orléans, BP 6759, 45067, Orléans Cedex 02, France

    A. Salvador, B. Herbreteau & M. Dreux

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  1. A. Salvador
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  2. B. Herbreteau
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  3. M. Dreux
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Salvador, A., Herbreteau, B. & Dreux, M. Preliminary studies of supercritical-fluid chromatography on porous graphitic carbon with methylated cyclodextrin as chiral selector. Chromatographia 53, 207–209 (2000). https://doi.org/10.1007/BF02491572

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  • DOI: https://doi.org/10.1007/BF02491572

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