Abstract
The radioactivity disappearance curves of glucose-6-14C albumin-I131 after a single injection of tracer into a human subject have been determined in detail, particularly at early time intervals. The curves, expressed as sums of exponentials, have been analyzed as the infinite sum of convolutions of single passage time densities. The resultant transfer time distribution of a single circulatory pass allows examination of all delays in the system no matter how long they take. The structural detail evident by this means and the long mean time of a single pass of glucose (>5 min) supports the thesis that factors other than rapid and uniform diffusion play a role in the extravascular movements of glucose molecules.
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This study was supported by Public Health Service Grants CA 07123 from the National Cancer Institute and RR 00044 from the Division of Research Facilities and Resources, N.I.H.
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Waterhouse, C., Keilson, J. Transfer times across the human body. Bulletin of Mathematical Biophysics 34, 33–44 (1972). https://doi.org/10.1007/BF02477022
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DOI: https://doi.org/10.1007/BF02477022