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Distribution In Vivo

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Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

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Abstract

Distribution studies with radiolabeled test substances in animals are an important part of the drug development process. Traditional routine methods used for these studies are quantitative tissue distribution studies (QTD) and alternatively whole-body autoradiography (WBA) with detection of the radioactivity in whole-body sections on X-ray film (Baker, Autoradiography: a comprehensive overview, microscopy handbooks 18. Oxford University Press/Royal Microscopical Society, Oxford/New York, 1989). WBA is a qualitative detection method with a very high local resolution which includes all organs and many small substructures.

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References and Further Reading

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  • Stumpf WE (2003) Drug localization in tissues and cells, receptor microscopic autoradiography. IDDC-Press/International Institute of drug distribution, cytopharmacology and cytotoxicology, Chapel Hill. ISBN 0-9740515-0-0

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  • Ullberg S (1954) Studies on the distribution and fate of S-35 – labelled benzylpenicillin in the body. Acta Radiol 118(Suppl):1–110

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Author information

Authors and Affiliations

  1. DI & A DMPK, Sanofi Pharma Deutschland GmbH, Industriepark Höchst, Frankfurt, Germany

    Manfred Zimmer

Authors
  1. Manfred Zimmer
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Editor information

Editors and Affiliations

  1. CorDynamics, Dieburg, Hessen, Germany

    Franz J. Hock

  2. CorDynamics, Chicago, IL, USA

    Michael R. Gralinski

  3. Cytokinetics (United States), South San Francisco, CA, USA

    Michael K. Pugsley

Section Editor information

  1. Toxicology, Cytokinetics, South San Francisco, CA, USA

    Michael K. Pugsley

  2. self employes, Dieburg, Deutschland

    Franz J. Hock DSc

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Zimmer, M. (2022). Distribution In Vivo. In: Hock, F.J., Gralinski, M.R., Pugsley, M.K. (eds) Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer, Cham. https://doi.org/10.1007/978-3-030-73317-9_42-1

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  • DOI: https://doi.org/10.1007/978-3-030-73317-9_42-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-73317-9

  • Online ISBN: 978-3-030-73317-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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