Abstract
This study attempts to define early carcinoma of the extrahepatic bile duct through a study of 11 patients whose carcinomatous invasion did not extend to the outer layer of the bile duct. The patients were divided into the following 3 groups, namely; a mucosa group comprised of 3 patients, a fibromuscular layer group comprised of 5 patients, and an adventitia group comprised of 3 patients. None of the patients had any lymphnode metastases. Histological characteristics were determined according to infiltrative growth (INFα, β, γ), lymphatic invasion (ly), venous invasion (v) and perineural invasion (pn). In the mucosa group, INFα was observed in 2 patients, while ly, v, and pn factors were all negative. In the fibromuscular layer group, INFβ was seen in 3 patients, ly was positive in 2 patients, while v, and pn factors were negative in all patients. In the adventitia group, INFγ was found in 2 patients, and ly, v, and pn factors were positive in all patients except for 1 in whom v was negative. Death from recurrence occurred in all the adventitia group patients and in 1 other patient. Early carcinoma of the extrahepatic bile duct could therefore be defined at present, as being carcinoma confined to within the mucosa and fibromuscular layer.
Similar content being viewed by others
References
Japanese Society of Biliary Surgery. General rules for surgical and pathological studies on cancer of biliary tract. 2nd ed. Tokyo: Kanehara Publishing, 1986; 47–54 (in Japanese)
Tsuchiya R, Noda T, Harada N, Miyamoto T, Tomioka T, Yamamoto K, Izawa K, Tsunoda T, Yoshino R, Eto T. Collective review of small carcinomas of the pancreas. Ann Surg 1986; 203; 77–81.
Japanese Research Society for Gastric Cancer. The general rules for the gastric cancer study in surgery and pathology. Part. Clinical classification. Jpn J Surg 1981; 11: 127–139.
19th Japan Biliary Association Proceedings. Early carcinoma of extrahepatic bile duct. In Kasai Y, ed. 1983; 258–355. (in Japanese)
Kozuka S, Tsubone M, Hachisuka K. Evolution of carcinoma in the extrahepatic bile ducts. Cancer 1984; 54: 65–72.
Tsunoda T, Tsuchiya R, Harada N, Noda T, Yamamoto K. Surgical treatment for carcinoma of the extrahepatic bile duct. Jpn J Surg 1985; 15: 123–129.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tsunoda, T., Eto, T., Koga, M. et al. Early carcinoma of the extrahepatic bile duct. The Japanese Journal of Surgery 19, 691–698 (1989). https://doi.org/10.1007/BF02471720
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02471720