Abstract
Continuous measurements of blood flow and partial pressures of physiological gases have been made simultaneously in the same structure of the brain. This was made possible by the development of 2 techniques (a) blood flow measurement by a thermal clearance technique using a single probe heated sequentially (b) tissue gas partial pressure measurement by means of mass spectrometric analysis of minute amounts of gas drawn out of the tissue via an implanted cannula. Probe responses were linear functions of the 2 variables measured, and observed variations could therefore be expressed as a percentage of meanbase line level. As the probes were implanted chronically, these measurements could be repeated over several days in unanaesthetised animals.
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Seylaz, J., Pinard, E., Dittmar, A. et al. Measurement of blood flow, tissue PO2 and tissue PCO2 continuously and simultaneously in the same structure of the brain. Med. Biol. Eng. Comput. 17, 19–24 (1979). https://doi.org/10.1007/BF02440949
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DOI: https://doi.org/10.1007/BF02440949