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Dimebon improves learning in animals with experimental Alzheimer's disease

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Systemic administration of antihistamine drug dimebon improves active avoidance conditioning in rats with chronic partial deprivation of cerebral cholinergic functions caused by intracerebroventricular injections of AF64A. The effects of dimebon on learning are similar to those of tacrine used in the treatment of Alzheimer's disease.

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Authors and Affiliations

  1. Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region

    N. N. Lermontova, N. V. Lukoyanov, T. P. Serkova, E. A. Lukoyanova & S. O. Bachurin

Authors
  1. N. N. Lermontova
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  2. N. V. Lukoyanov
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  3. T. P. Serkova
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  4. E. A. Lukoyanova
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  5. S. O. Bachurin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 6, pp 640–642, June, 2000

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Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P. et al. Dimebon improves learning in animals with experimental Alzheimer's disease. Bull Exp Biol Med 129, 544–546 (2000). https://doi.org/10.1007/BF02434871

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  • DOI: https://doi.org/10.1007/BF02434871

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