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Update on proliferation-associated antibodies applicable to formalin-fixed paraffin-embedded tissue and their clinical applications

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Summary

This review provides an update on proliferation-associated antibodies applicable to immunohistochemical techniques in formalin-fixed paraffin-embedded tissue. New insights into proliferating cell nuclear antigen (PCNA) and antibodies to PCNA are presented. The characterization of the protein recognized by the Ki-67 antibody has enabled production of a new range of antibodies (monoclonal and polyclonal) which have immunostaining profiles similar to those of the original antibody. A new proliferation-associated antibody, KiS1, is described. The clinical applications of antibodies to PCNA in human material are summarized, and the limitations of these studies are discussed.

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  1. Department of Histopathology, United Medical and Dental Schools of Guy's and St Thomas's Hospitals (UMDS), Guy's Campus, St Thomas's Street, SE1 9RT, London, UK

    Carmen C. -W. Yu & M. Isabel Filipe

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  1. Carmen C. -W. Yu
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Yu, C.C.W., Filipe, M.I. Update on proliferation-associated antibodies applicable to formalin-fixed paraffin-embedded tissue and their clinical applications. Histochem J 25, 843–853 (1993). https://doi.org/10.1007/BF02388205

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