Abstract
15 patients with remitting-progressive multiple sclerosis received a course of intravenous cyclophosphamide followed by a booster dose every 60 days for 2 years. There were no severe short or medium term side effects. Half of the patients presented clinical stabilization and substantially unchanged Kurtzke rating at 2 year follow-up. Since the aim was stabilization only, our findings argue for continuation of the study in young patients with very short shift.
Sommario
15 pazienti affetti da sclerosi multipla remittente-progressiva, sono stati sottoposti a ciclo di CTX endovena con richiami ogni sessanta giorni. Non ci sono stati pesanti effetti collaterali a breve e medio termine. A due anni di follow-up il 50% dei pazienti ha mostrato una stabilizzazione della malattia.
I dati orientano per una continuazione dello studio su pazienti con giovane età e passaggio dalla forma remittente a remittente-progressiva da breve tempo.
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Millefiorini, E., Di Giovanni, M., Bernardi, S. et al. 24-month follow-up of multiple sclerosis patients treated with cyclophosphamide. Ital J Neuro Sci 11, 605–607 (1990). https://doi.org/10.1007/BF02337446
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DOI: https://doi.org/10.1007/BF02337446