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Role of 5-hydroxytryptamine in gastrointestinal chemosensitivity

  • Section II: Feedback Regulation And Sensation
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Abstract

The present electrophysiological investigation examines the effect of 5-hydroxytryptamine (5-HT) on gastrointestinal afferent fiber discharge. 5-HT markedly and specifically stimulated vagal mucosal chemosensitive afferents. The response was mediated by 5-HT3 receptors as demonstrated by the action of 2-methyl-5-HT and antagonism by granisetron. At doses of granisetron that completely block the response to 5-HT, the afferent fibers still responded to both mechanical and chemical stimulation of the mucosa. This sensitivity of extrinsic afferents is in marked contrast to that reported for intrinsic afferents, suggesting fundamental differences in the organization of enteric and vagal reflexes.

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Authors and Affiliations

  1. From the Department of Biomedical Science, The University of Sheffield, S10 2TN, Sheffield, U.K.

    D. Grundy, L. A. Blackshaw & K. Hillsley

Authors
  1. D. Grundy
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  2. L. A. Blackshaw
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  3. K. Hillsley
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Additional information

The MRC is thanked for financial support. K.H. is a postgraduate student funded by the SERC.

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Grundy, D., Blackshaw, L.A. & Hillsley, K. Role of 5-hydroxytryptamine in gastrointestinal chemosensitivity. Digest Dis Sci 39 (Suppl 12), 44S–47S (1994). https://doi.org/10.1007/BF02300369

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  • DOI: https://doi.org/10.1007/BF02300369

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