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Luminal Chemoreceptors and Intrinsic Nerves: Key Modulators of Digestive Motor Function

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The Enteric Nervous System II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1383))

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Abstract

This chapter reviews data on the pathways by which luminal, mainly duodenal, chemoreceptors modulate gastro-pyloro-duodenal motor function to control emptying of nutrients into the small intestine. The vagus mediates proximal gastric relaxation caused by nutrient stimulation of duodenal/jejunal mucosal chemoreceptors. Modulation of the spatial patterning and inhibition of antral contractions during duodenal chemoreceptor activation are somewhat conflicting: both vagal control and ascending intramural nerves appear to play a role. Intraduodenal nutrients stimulate the localized pyloric contractions that prevent transpyloric flow via ascending duodenal intramural nerve pathways. Though not yet formally investigated, patterns of activation of the duodenal brake motor mechanism suggest that duodenal loop mucosal chemoreceptors signal to a brake mechanism at the most aborad region of the duodenum via descending intramural duodenal nerves.

Intrinsic intramural pathways are important in the control of the first stages of digestion.

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Author information

Authors and Affiliations

  1. Royal Adelaide Hospital, Adelaide, SA, Australia

    John Dent

  2. Gastroenterology Unit, Flinders Medical Centre & College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia

    Phil G. Dinning

Authors
  1. John Dent
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  2. Phil G. Dinning
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Corresponding author

Correspondence to Phil G. Dinning .

Editor information

Editors and Affiliations

  1. College of Medicine & Public Health Flinders Medical Centre, Adelaide, SA, Australia

    Nick J. Spencer

  2. College of Medicine & Public Health Flinders Medical Centre, Adelaide, SA, Australia

    Marcello Costa

  3. South Australian Health & Medical Research Institute, Adelaide, SA, Australia

    Stuart M. Brierley

Additional information

Dedication

JD dedicates this chapter to Edwin (“Ed”) E Daniel, the most scientifically omnivorous and inquisitive person he has ever had the good fortune to work with.

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Dent, J., Dinning, P.G. (2022). Luminal Chemoreceptors and Intrinsic Nerves: Key Modulators of Digestive Motor Function. In: Spencer, N.J., Costa, M., Brierley, S.M. (eds) The Enteric Nervous System II. Advances in Experimental Medicine and Biology, vol 1383. Springer, Cham. https://doi.org/10.1007/978-3-031-05843-1_3

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