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Cyclization of N-allylthiourea derivatives by the action ofα-chloronitrosoalkanes

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A convenient method is proposed for obtaining difficultly available derivatives of 2-amino-5-chloromethyl-2-thiazoline by the cyclization of N-allythioureas under the action ofα-chloronitrosoalkanes. It is assumed that the reaction proceeds as a halogenophilic process leading to the intermediate formamidinesulfenyl chloride which is rapidly and selectively cyclized with the formation of 2-amino-2-thiazoline derivatives.

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Authors
  1. S. E. Tkachenko
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  2. A. N. Pushin
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  3. V. B. Sokolov
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  4. V. M. Fedoseev
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  5. I. V. Martynov
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Additional information

Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka 142432, Russia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 381–384, March, 1998.

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Tkachenko, S.E., Pushin, A.N., Sokolov, V.B. et al. Cyclization of N-allylthiourea derivatives by the action ofα-chloronitrosoalkanes. Chem Heterocycl Compd 34, 347–350 (1998). https://doi.org/10.1007/BF02290730

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  • DOI: https://doi.org/10.1007/BF02290730

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