Skip to main content
Log in

Intracranial metastases of hepatocellular carcinoma: CT and MRI

  • Diagnostic Neuroradiology
  • Published:
Neuroradiology Aims and scope Submit manuscript

Abstract

We report clinical characteristics and CT and MRI in 16 patients with brain metastases due to hepatocellular carcinoma (HCC). Eight of these 16 patients presented with apoplexy-like symptoms (50 %). Pulmonary metastases were found in 13 cases (81.3 %). The mean survival from the appearance of cerebral metastases to death was 6.2 weeks, which is one of the shortest survival terms in metastatic brain tumours. Haemorrhagic brain metastases were observed in 14 patients (87.5 %) with a tendency for the frequency of bleeding to increase in proportion to the size of the tumour. On both contrast-enhanced CT and MRI, metastatic brain tumours enhanced strongly, suggesting that brain metastases, like HCC, are also hypervascular. MRI is useful in evaluating brain metastases from HCC, especially in order to differentiate tumour from haemorrhage. Our results demonstrated a poor prognosis and bleeding tendency of brain metastases due to HCC and showed the usefulness of CT and MRI in achieving a correct diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Liver Cancer Study Group of Japan (1993) Survey and follow-up study of primary liver cancer in Japan. Report 10 (in Japanese). Acta Hepatol Jpn 34: 805–813

    Google Scholar 

  2. Chang YC, Chen RC (1979) Craniospinal and cerebral metastasis of primary hepatomas. A report of 7 cases. J Formosan Med Assoc 78: 594–604

    Google Scholar 

  3. Matso H, Shirabe I, Kinoshita I, et al (1988) Brain metastases of hepatocellular carcinoma: a case report (in Japanese). J Jpn Soc Intern Med 77: 842–846

    Google Scholar 

  4. Kawaguchi T, et al (1982) Difference in prolifiration-kinetics between tumor cells arrested in the brain and liver. Experientia 38: 1236

    Google Scholar 

  5. Yoshikawa S, Kijima H, Ichikawa H, et al (1988) A case of brain metastases due to hepatocellular carcinoma which can be surgically removed (in Japanese). Jpn J Cancer Clin 34: 457–461

    Google Scholar 

  6. Imanaka K, Takahashi M, Sadatou N, et al (1987) Radiation therapy for metastases of hepatocellular carcinoma (in Japanese). Jpn J Cancer Clin 33: 1892–1896

    Google Scholar 

  7. Uchino A, Miyoshi T, Ohno M, et al (1987) Solitary pontine metastasis from hepatocellular carcinoma: a case report. Radiat Med 5: 99–100

    Google Scholar 

  8. Otsuka S, Fukumitsu T, Yamamoto T, et al (1987) Brain metastasis of hepatocellular carcinoma presenting with hemorrhage. Case report. Neurol Med Chir (Tokyo) 27: 654–657

    Google Scholar 

  9. Lee JP, Lee ST (1988) Hepatocellular carcinoma presenting as intracranial metastasis. Surg Neurol 30: 316–320

    Google Scholar 

  10. Shuangshoti S, Rungruxsirivorn S, Panyathanya R (1989) Intracranial metastasis of hepatic carcinomas: a study of 9 cases within 28 years. J Med Assoc Thai 72: 307–313

    Google Scholar 

  11. Scott M (1975) Spontaneus intracerebral hematoma caused by cerebral neoplasms. J Neurosurg 42: 338–342

    Google Scholar 

  12. Mandybur TI (1977) Intracranial hemorrhage caused by metastatic tumors. Neurology 27: 650–655

    Google Scholar 

  13. Geldersleeve N, Koo AH, Macdonald CJ (1977) Metastatic tumor presenting as intracerebral hemorrhage. Radiology 124:109–112

    Google Scholar 

  14. Weisberg LA (1985) Hemorrhagic metastatic intracranial neoplasms: clinical-computed tomographic correlations. Comput Radiol 9: 105–114

    Google Scholar 

  15. Doel EMH van den, Merrienboer FJJM van, Tuleken CAF (1985) Cerebral hemorrhage from unsuspected choriocarcinoma. Clin Neurol Neurosurg 87: 287–290

    Google Scholar 

  16. Atras SW, Grossman RI, Gomori JM, et al (1987) Hemorrhagic intracranial malignant neoplasms: spin-echo MR imaging. Radiology 164: 71–77

    Google Scholar 

  17. Russell EJ, Geremia GK, Johonson CE, et al (1987) Multiple cerebral metastases: detectability with Gd-DTPAenhanced MR imaging. Radiology 165: 609–617

    Google Scholar 

  18. Healy ME, Hesselink JR, Press GA, et al (1987) Increased detection of intracranial metastases with intravenous GdDTPA. Radiology 165: 619–624

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Murakami, K., Nawano, S., Moriyama, N. et al. Intracranial metastases of hepatocellular carcinoma: CT and MRI. Neuroradiology 38 (Suppl 1), S31–S35 (1996). https://doi.org/10.1007/BF02278115

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02278115

Key words

Navigation