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Enantiomeric composition of urinary salsolinol in Parkinsonian patients after Madopar

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Journal of Neural Transmission - Parkinson's Disease and Dementia Section

Summary

Urinary salsolinol output had been shown to be lower in Parkinsonian patients than in controls and to increase largely after L-dopa therapy. It had also been established that the R enantiomer of salsolinol is either the predominant or the sole enantiomer present in the urine of healthy subjects.

When Madopar was administered to Parkinsonians, the enantiomeric composition of urinary salsolinol showed an S/R ratio around 1. Considering brain and plasma concentrations in dopamine, acetaldehyde and pyruvate, it is suggested that, under physiological conditions, urinary salsolinol should have a central origin in humans. Conversely, urinary salsolinol in Madopar-treated Parkinsonian patients might be predominantly formed at the periphery.

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Author notes

  1. P. Dostert

    Present address: Research and Development-Erbamont Group, Farmitalia Carlo Erba, Via Imbonati 24, I-20159, Milan, Italy

Authors and Affiliations

  1. Research and Development-Erbamont Group, Farmitalia Carlo Erba, Via Imbonati 24, I-20159, Milan, Italy

    M. Strolin Benedetti

  2. Service de Neurologie, Hôpital Nord, Clermont-Ferrand, France

    G. Dordain & D. Vernay

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  1. P. Dostert
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  2. M. Strolin Benedetti
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  3. G. Dordain
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  4. D. Vernay
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Dostert, P., Benedetti, M.S., Dordain, G. et al. Enantiomeric composition of urinary salsolinol in Parkinsonian patients after Madopar. J Neural Transm Gen Sect 1, 269–278 (1989). https://doi.org/10.1007/BF02263481

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  • DOI: https://doi.org/10.1007/BF02263481

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