Abstract
A monoamine oxidase hypothesis for the cause of attention deficit hyperactivity disorder has recently been established (Shekim et al. 1986). To test this, moclobemide, a new and reversible inhibitor of monoamine oxidase-A, was administered to 12 children between the ages of 6 and 13 years, diagnosed as attention deficit hyperactive according to DSM III-R, in a 4-week study. All had previously discontinued treatment with methylphenidate due to side-effects. A 40% improvement in parental assessment of children's behaviour occurred among those who received moclobemide as outpatients, and a 31% improvement among the five in-patients. There was a general increase in concentration and attention span at the end of the trial, but mood changes and explosive behaviour continued to be present at a low level. Brain mapping after moclobemide treatment showed an overall reduction in frontal lobe delta activity. Moclobemide was well tolerated by these patients, although two complained of mild gastrointestinal disturbances during the first week of therapy.
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References
Bradley C (1937) The behaviour of children receiving benzedrine. Am J Psychiatry 94:577–585
Conners CK (1969) The teachers' rating scale for use in drug studies with children. Am J Psychiatry 126:884–888
Kruger HP (1989) Speech chronemics — a hidden dimension of speech. Theoretical background, measurement and clinical validity. Pharmacopsychiatry 22[suppl]:5–12
Porrino L., Rapoport J, Behar D, Ismond D, Bunney W (1983) A naturalistic assessment of the motor activity of hyperactive boys. Arch Gen Psychiatry 40:681–687
Shekim WO, Bylund DB, Alexon J (1986) Platelet MAO and measures of attention and impulsivity in boys with attention deficit disorder and hyperactivity. Psychiatry Res 18:179–188
Young JG, Cohen DJ, Waldo MD, Feiz R, Roth JA (1980) Platelet monoamine oxidase activity in children and adolescents with psychiatric disorders. Schizophren Bull 6[2]:324–333
Zametkin A, Rapoport JL, Murphy DL, Linnoila M, Ismond D (1985) Treatment of hyperactive children with monoamine oxidase inhibitors. Arch Gen Psychiatry 42[10]:962–966
Zametkin AJ, Nordahl TE, Gross M, King AC, Semple WE, Ramsey J, Hamburger S, Cohen RM (1990) Cerebral glucose metabolism in adults with hyperactivity of childhood onset. N Engl J Med 323:1361–1366
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Trott, G.E., Friese, H.J., Menzel, M. et al. Use of moclobemide in children with attention deficit hyperactivity disorder. Psychopharmacology 106 (Suppl 1), S134–S136 (1992). https://doi.org/10.1007/BF02246258
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DOI: https://doi.org/10.1007/BF02246258