Abstract
β-Adrenoceptor binding sites were measured by saturation binding of [3H]CGP 12177 in nine brain regions from 13 suicides, with a firm retrospective diagnosis of depression, who had been receiving antidepressant drugs, and 11 matched controls. Significantly lower numbers ofβ-adrenoceptor binding sites were found in thalamus and temporal cortex (Brodmann area 38), but not in other brain regions, of antidepressant-treated suicides compared to controls. The lower number ofβ-adrenoceptor binding sites in thalamus appeared to be related to drug treatment, whereas lower numbers ofβ-adrenoceptors in temporal cortex were also found in antidepressant-free suicides.
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De Paermentier, F., Cheetham, S.C., Crompton, M.R. et al. Brainβ-adrenoceptor binding sites in depressed suicide victims: effects of antidepressant treatment. Psychopharmacology 105, 283–288 (1991). https://doi.org/10.1007/BF02244323
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DOI: https://doi.org/10.1007/BF02244323