Summary
Two cases with prolapse of all four cardiac valves are described and compared with two similar ones previously reported. The severity and progression of regurgitation of each of the valves differed by case, despite having similar echocardiographic findings consistent with the diagnosis of multiple floppy valves. Two of the four patients had their aortic valve replaced because of severe regurgitation: the excised valves revealed myxomatous degeneration. None of the patients had any stigmata of Marfan or Ehlers-Danlos syndrome, except for the presence of hyperextensive joints. There may be an unknown collagen disorder that caused floppiness in all the valves.
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References
Brandt KD, Sumner RD Ryan TJ, Cohen AS (1975) Herniation of mitral leaflets in the Ehlers-Danlos syndrome.Am J Cardiol 36:524–528
Chandrarantna PAN, Nimalasuriya A, Kawanishi D, Duncan P, Rosin B, Rahimtoola SH (1984) Identification of the increased frequency of cardiovascular abnormalities associated with mitral valve prolapse by two-dimensional echocardiography.Am J Cardiol 54:1283–1285
Frable WJ (1969) Mucinous degeneration of cardiac valves: The floppy valve syndrome.J Thorac Cardiovasc Surg 58:62–70
Handler CE, Child A, Light ND, Dorrance DE (1985) Mitral valve prolapse, aortic compliance and skin collagen in joint hypermobidity syndrome.Br Heart J 54:501–508
Jaffe AS, Geltman EM, Rodey GE, Uitto J (1981) Mitral valve prolapse: A consistent manifestation of type IV Ehlers-Danlos syndrome.Circulation 64:121–125
Malcom A (1985) Mitral valve prolapse associated with other disorders.Br Heart J 53:353–362
Morganroth J, Jones RH (1980) Two-dimensional echocardiography in mitral, aortic and tricuspid valve prolapse.Am J Cardiol 46:1164–1177
Nakamura K, Suzuki S Sakakibara S, Komatsu Y, Takahashi S, Hirosawa K (1980) M-mode and cross-sectional echocardiographic features of frail pulmonary valve.Jpn Heart J 21:897–902
Ogawa S, Hayashi J, Sasaki H, Tani M, Akaishi M, Mitamura H, Sano M, Hoshino T, Handa S, Nakamura Y (1982) Evaluation of combined valvular prolapse syndrome by two-dimensional echocardiography.Circulation 65:174–180
Patitalot JP, Chaix AF, Barraine R (1986), Echocardiographic features of triple valve prolapse with incompetent foramen ovale in Marfan's syndrome.Am Heart J 111:187–189
Read RC, Thal AP, Wendt VE (1965) Symptomatic valvular myxomatous transformation (The floppy valve syndrome).Circulation 32:897–910
Rippe JM, Angoff G, Sloss LJ, Wynne J, Alpert JS (1979) Multiple floppy valves: An echocardiographic syndrome.Am J Med 66:817–824
Roberts WC, Honig HS (1982) The spectrum of cardiovascular disease in the Marfan syndrome.Am Heart J 104:115–135
Robinson PJ, Wyse RKH, Macartney FJ (1984) Significance of pulmonary valve prolapse.Br Heart J 52:266–271
Suzuki K, Murakami Y, Konishi T, Mori K Mimori S (1987) A report of two siblings with multiple floppy valves: All four cardiac valves prolapsing. [English abstract]Journal of the Japan Pediatric Society 91:765–773
Vandenbossche JL, Englert M (1983) Echocardiographic detection of associated pulmonary and mitral valve prolapse.Chest 83:159–160
Warth DC, King ME, Cohen JM, Tesoriero VL, Marcus E, Weyman AE (1985) Prevalence of mitral valve prolapse in normal children.JACC 5:1173–1177
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Suzuki, K., Murakami, Y., Mori, K. et al. Multiple floppy valves with all cardiac valves prolapsing: Clinical course and treatment. Pediatr Cardiol 12, 110–113 (1991). https://doi.org/10.1007/BF02238415
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DOI: https://doi.org/10.1007/BF02238415