Summary
Liver biopsy and function tests were performed on 8 patients with tropical sprue. Although mild hepatic siderosis and lipofuscin deposition were revealed in addition to some minimal abnormalities in liver function tests, no evidence of significant hepatic injury was found.
Similar content being viewed by others
References
Suarez, R. M. Clinical and hematological review of sprue based on the study of 150 cases.Ann. Int. Med. 12:529, 1938.
Rodriguez-Molina, R. Fundamental concepts in the diagnosis of sprue.Ann. Int. Med. 40:33, 1954.
Asenjo, C. F. Criteria for assessing fat absorption in normal subjects and sprue patients.Am. J. Trop. Med. 1:344, 1952.
Vega, G., Floch, M. H., andHaddock, L. Hypotassemia in tropical sprue. Eleventh Annual Regional Meeting of the American College of Physicians. Puerto Rico, 1961.
Butterworth, C. E., Jr., andPerez-Santiago, E. Jejunal biopsies in sprue.Ann. Int. Med. 48:8, 1958.
Thurlbeck, W. M., Benson, J. A., Jr., andDudley, H. R., Jr. Histopathologic changes in sprue and their significance.Am. J. Clin. Path. 34:108, 1960.
Floch, M. H., Thomassen, R. W., Cox, R. S., andSheehy, T. W. The gastric mucosa in tropical sprue. To be published, 1962.
Suarez, R. M., Spies, T. D., andSlarez, R. M., Jr. The use of folic acid in sprue.Ann. Int. Med. 26:643, 1947.
Menghini, G. Two-operator needle biopsy of the liver.Am. J. Dig. Dis. 4:682, 1959.
Manual of Histologic and Special Staining Technics. Armed Forces Institute of Pathology. Washington, D. C., 1957.
Little, R. D. Histopathologic and Practical Histochemistry. McGraw-Hill. New York. 1954.
Palmer. E. D. Gastritis, a revaluation.Medicine 33:199, 1954.
Keys, A., Brozek, J., Henschel, A., Mickelsen, O., andTaylor, H. L. The Biology of Human Starvation, I. Univ. Minnesota Press, Minneapolis, 1950, p. 192.
Sepulneda, B., Hernandez de la Porthla, R., Rojas, E., andDr. J. Macins, J. Las alteraciones del higado en la desnutricion.Rev. Invest. Clin., 9:445. 1957.
Johnson, F. B., Hamilton, P. K., andGridley, M. F. The pigment of schistosomiasis.J. Histochem. & Cytochem. 2:481, 1954.
Dubin, I. N. andJohnson, F. B. Chronic idiopathic jaundice with unidentified pigment in liver cells.Medicine 33:155, 1954.
Pearse, A. G. E. Histochemistry, Theoretical and Applied, ed. 2. Little. Boston, 1960.
Popper, H., andSchaffner, F. Liver: Structure and Function. McGraw-Hill, New York. 1957. p. 20.
Schiff, L. Diseases of the Liver. Lippincott. Philadelphia. 1956. p. 500.
Zimmerman, H. J., Chomet, B., Kulesh, M. H., andMcWhorter, C. A. Hepatic hemosiderin deposts.A.M.A. Atch. Int. Med., 107:494. 1961.
Dominici, G., Menghini, G., Dalla Torre, M., andOrlandi, F. Siderosis and chromatosis of the liver.Rev. Int. Hepat. 8:1, 1958.
MacDonald, R. A. Idiopathic hemochromatosis.A.M.A. Arch. Int. Med. 107:606, 1961.
Hughes, J. T., andTruelone, L. H. Transfusional hemosiderosis simulating hemochromatosis.J. Clin. Path. 11:128, 1958.
Bradlow, B. A., Dunn, J. A., andHigginson, J. The effect of cirrhosis on iron storage.Am. J. Path. 39:221, 1961.
Buetler, E., Robson, M. J., andButtenwieser, E. A comparison of the plasma iron, iron-binding capacity, sternal marrow iron and other methods in the clinical evaluation of iron stores.Ann. Int. Med. 48:60, 1958.
Sheehy, T. W., Rubini, M. E., Baco-Dapena, R., andPerez-Santlago, E. Erythrokinetics in the megaloblastic anemia of tropical sprue.Blood 15:761, 1960.
Gillman, J., andGillman, T. Structure of the liver in pellagra.A.M.A. Arch. Path. 40:239, 1945.
Kelly, M., andTerry, R. Clinical and histological observations in fatal nontropical sprue.Am. J. Med. 25:460, 1958.
Himes, H. W., andAdlersberg, D. Pathologic studies in idiopathic sprue.J. Ml. Sinai Hosp. 24:251, 1957.
Adlersberg, D., andSchein, J. Clinical and pathological studies in sprue.J.A.M.A.,134:1459, 1947.
Sherlock, S., andWalshe, V. Effect of undernutrition in man on hepatic structure and function.Nature 161:601, 1948.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Floch, M.H., Thomassen, R.W., Guerra, R. et al. The structural and functional status of the liver in tropical sprue. Digest Dis Sci 8, 344–352 (1963). https://doi.org/10.1007/BF02237708
Issue Date:
DOI: https://doi.org/10.1007/BF02237708