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The effects of glucagon and glucose on the human stomach

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Conclusions

Glucagon given by continuous intravenous infusion consistently decreases the gastric acid and pepsin output of human subjects for several hours. Ten per cent glucose produces varying depressions in gastric acid and pepsin output. In humans, glucose and glucagon together act consistently to raise the gastricpH and to lower the gastric pepsin concentration throughout the period of administration.

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References

  1. Zollinger, R. M., andEllison, E. H. Primary peptic ulceration of the jejunum associated with islet cell tumors of the pancreas.Ann. Surg. 142:709, 1955.

    PubMed  Google Scholar 

  2. Robinson, R. M., Harris, K., Hlad, C. J., andEisman, B. Effect of glucagon on gastric secretion.Proc. Soc. Exper. Biol. & Med. 96:518, 1957.

    Google Scholar 

  3. Stunkard, A. J., Van Itallie, T. B., andReiss, B. B. Effect of glucagon on gastric hunger contractions in man.Proc. Soc. Exper. Biol. & Med. 89:258, 1955.

    Google Scholar 

  4. Earle, A. S., Cahill, G. F., andHoar, C. S. Studies on the relationship of glucagon to blood pepsinogen level.Ann. Surg. 146:124, 1957.

    PubMed  Google Scholar 

  5. Mayo, H. W., Jr., andEmerson, D. M. Endocrine influences of the pancreas on gastric secretion.Surgery 44:91, 1958.

    PubMed  Google Scholar 

  6. Babkin, B. P. Secretory mechanisms of the digestive glands. New York, Hoeber, 1950.

    Google Scholar 

  7. Nelson, N. A photometric adoption of the Somogyi method for the determination of glucose.J. Biol. Chem. 153:375, 1944.

    Google Scholar 

  8. Somogyi, M. A new reagent for the determination of sugars.J. Biol. Chem. 160:61, 1945.

    Google Scholar 

  9. Anson, M. T. The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin.J. Gen. Physiol. 22:79, 1938.

    Article  Google Scholar 

  10. Elrick, H., Hlad, C. J., Jr., Arai, Y., andSmith, A. Interaction of glucagon and insulin on blood glucose.J. Clin. Invest. 35:757, 1956.

    PubMed  Google Scholar 

  11. Staub, A., Sprives, V., andElrick, H. Renal action of glucagon.Proc. Soc. Exper. Biol. & Med. 94:57, 1957.

    Google Scholar 

  12. Dreiling, D. A., andJanowitz, H. D. The effect of glucagon on gastric secretion in man.Gastroenterology 36:580, 1959.

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. From the Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn.

    Sanford P. Solomon M.D. & Howard M. Spiro M.D.

Authors
  1. Sanford P. Solomon M.D.
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  2. Howard M. Spiro M.D.
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Additional information

Aided in part by grants C-2578 and A-1785 from the U. S. Public Health Service.

We are grateful to Mrs. Julia Zalokar, of the Bio-Statistics Department, for her evaluation from a statistical standpoint of this material; and to Mr. Joseph Coscia, Mrs. Nancy Iannotti, Mrs. Felicia Mestel, and Miss Bea Pask, for their technical assistance.

Crystalline glucagon, Lot #0358-PA-60923, AX 29821, was kindly supplied by Dr. Glenn W. Irwin, of Lilly Laboratories.

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Solomon, S.P., Spiro, H.M. The effects of glucagon and glucose on the human stomach. Digest Dis Sci 4, 775–786 (1959). https://doi.org/10.1007/BF02237685

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  • DOI: https://doi.org/10.1007/BF02237685

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