Abstract
The hormonal phase of gastric-acid secretion is mediated by the gastrins and it has been shown that the full range of physiologic actions of these heptadeca-peptides can be elicited by the C-terminal tetrapeptide-Trp-Met-Asp-Phe-NH2. A variety of analogs has been prepared to study the structural features causing the release of gastric acid, and to attempt to inhibit the action of the parent hormone. The synthesis and biologic actions of these peptides are discussed, and reference is made to a natural inhibitor of gastric-acid secretion isolated from urine.
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The author wishes to thank Mr. E. Gerring, Mrs. E. Haworth, and Dr. J. Raventos for the biological work carried out in the studies on urogastrone; Mrs. E. Tidswell. Mr. I. Willshire, Mr. W. Broadbent, and Mr. R. Goodwin for their willing and skillful technical assistance.
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Gregory, H. Some polypeptides influencing gastric-acid secretion. Digest Dis Sci 15, 141–148 (1970). https://doi.org/10.1007/BF02235645
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DOI: https://doi.org/10.1007/BF02235645