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Effect of metoclopramide on gastrointestinal motility in man

A manometric study

  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

The effect of metoclopramide on intraluminal pressure of the human gastrointestinal tract was studied by means of tubes and radiopills. Intravenous metoclopramide, 20 mg, stimulates pressure in the stomach, and small and large intestine, but not in the sigmoid and rectum. Metoclopramide induces vigorous antral contractions that are followed by duodenal pressure waves which exhibit a particular phasic activity. During this activity, the radiopill passes rapidly through the small intestine. A reciprocal correlation between pressure and movement of the radiopill was found in the small intestine; no correlation could be detected in the large intestine.

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Authors and Affiliations

  1. From the Department of Gastroenterology, Medizinische Universitätsklinik, Bürgerspital, Basel, Switzerland

    Martin Eisner MD

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  1. Martin Eisner MD
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Eisner, M. Effect of metoclopramide on gastrointestinal motility in man. Digest Dis Sci 16, 409–419 (1971). https://doi.org/10.1007/BF02235085

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  • DOI: https://doi.org/10.1007/BF02235085

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