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Nephrolithiasis in inflammatory bowel disease

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Abstract

In a series of 885 patients with inflammatory bowel disease, 64 (7.2%) also had nephrolithiasis. Forty-three patients (6.4%) had ulcerative colitis, and 21 (10.1%) had “granulomatous” inflammatory bowel disease. The majority of patients were young men with ulcerative colitis. The average duration of the bowel disease prior to the clinical diagnosis of renal calculi was 10 years. Calcium radiopaque stones were identified by chemical analysis or X-ray appearance in 46 patients. Uric acid radiolucent calculi similarly were identified in 12 patients. In 6 patients the stones could not be classified. Increased concentration and excretion of urinary crystalloids, possibly related to the administration of adrenal corticosteroids, persistent excretion of an acid urine, and intestinal surgery, may be important factors in the pathogenesis of nephrolithiasis in inflammatory bowel disease; but further metabolic studies are necessary to clarify this problem.

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Authors and Affiliations

  1. Department of Medicine, University of Chicago, 950 E. 59th St., 60637, Chicago, Ill.

    Eugene A. Gelzayd M.D., Richard I. Breuer M.D. &  Joseph B. Kirsner M.D.

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  1. Eugene A. Gelzayd M.D.
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  2. Richard I. Breuer M.D.
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  3. Joseph B. Kirsner M.D.
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Additional information

Supported in part by Grant AM-02133 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U. S. Public Health Service.

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Gelzayd, E.A., Breuer, R.I. & Kirsner, J.B. Nephrolithiasis in inflammatory bowel disease. Digest Dis Sci 13, 1027–1034 (1968). https://doi.org/10.1007/BF02233547

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