Summary
The small bowel of hypophysectomized rats was examined histologically and chemically. The following conclusions were made:
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1.
The diameter of the small bowel of hypophysectomized rats was smaller than that in normal controls. The villi were shorter, often broader and more blunt. Increased lymphocytic infiltration was noted in the jejunum, ileum, and colon.
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2.
The percent of weight of the entire small bowel in terms of total body weight was smaller in hypophysectomized rats. Both the dry and wet weights of the small bowel were significantly decreased in hypophysectomized rats.
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3.
No significant differences were found between the content of control and hypophysectomized animals with regard to protein, total nitrogen, phosphorus, P-RNA, and P-DNA of the small bowel, if the concentrations are expressed per gram of dry tissue.
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4.
Uronic acid and sialic acid were present in lesser amounts per gram of dry tissue as well as in the entire small bowel of hypophysectomized rats. By contrast, lipids were present in increased amounts.
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5.
All chemical components tested, except lipids, were present in lesser amounts in the entire small bowel of hypophysectomized rats.
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Supported by U. S. Public Health Service Research Grant AM-09332, and by Gastroenterology training Grant 5TIAM5424 from the National Institute of Arthritis and Metabolic Diseases.
We wish to thank Dr. Maurice S. Raben of the Department of Medicine of the New England Medical Center Hospitals, Boston, Mass. for his help and advice in the course of these studies.
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Havivi, Y., Havivi, E., Levitan, R. et al. Histology and chemical composition of the small bowel of hypophysectomized rats. Digest Dis Sci 13, 735–742 (1968). https://doi.org/10.1007/BF02232998
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DOI: https://doi.org/10.1007/BF02232998