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The effect of hypophysectomy on the gastrointestinal tract

A review of the literature

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Summary

After hypophysectomy, morphologic and physiologic changes occur in the digestive system of animals and probably of man. These changes appear to be a function of declining activity caused by the loss of various stimulating and regulatory substances secreted by the anterior pituitary. However, while a review of the literature seems to indicate an essential role for the hypophysis in various normal digestive tract functions, few data are available to indicate the extent of these actions, whether these are direct actions or operate through other endocrine systems.

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Authors and Affiliations

  1. From the Departments of Anatomy, Medicine (Division of Gastroenterology) and Surgery, University of Tennessee Medical Units, Memphis, Tenn.

    H. Schapiro PhD, L. D. Wruble MD & L. G. Britt MD

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  1. H. Schapiro PhD
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  2. L. D. Wruble MD
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  3. L. G. Britt MD
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Supported in part by NSF Grant GB-7687 and American Cancer Society IN-85C (U. T.).

The authors wish to acknowledge the library assistance of M. M. Blanton, MSLS (USPHS Grant LM-00102 from the National Library of Medicine).

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Schapiro, H., Wruble, L.D. & Britt, L.G. The effect of hypophysectomy on the gastrointestinal tract. Digest Dis Sci 15, 1019–1030 (1970). https://doi.org/10.1007/BF02232821

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