Abstract
The effects of an excessive intake of ethanol on gastric acid secretion was investigated up to 14 months in 6 dogs. After the daily administration of 4.4 g/kg of ethanol as a 40% solution through the esophagostomy was initiated, mean daily secretion of acid from a Heidenhain pouch increased from 5.22 to 12.55 mEq during the first month and remained elevated throughout the entire period of observation. The mean maximal acid output (MAO) increased also from 19.54 to 26.3 mEq within 1 month after the daily administration of ethanol began. The increased MAO, however, tended to decrease with the passage of time and at the end of 6 months, it was no different, statistically, from that of the pre-ethanol level. Factors possibly responsible for the increase in acid secretion are discussed.
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The authors thank Mrs. Shu-Hua Hsiao and Mrs. Carol Jean Brunner for their excellent technical assistance and Mrs. Shirley Braverman of the Department of Biometrics for statistical analysis of the data.
Supported by Grant NIMH 15614 from the United States Public Health Service.
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Chey, W.Y., Kosay, S. & Lorber, S.H. Effects of chronic administration of ethanol on gastric secretion of acid in dogs. Digest Dis Sci 17, 153–159 (1972). https://doi.org/10.1007/BF02232736
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DOI: https://doi.org/10.1007/BF02232736