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Direct effect of calcitriol on the regulation of parathyroid hormone secretion in a case of pseudo-hypoparathyroidism (a 24-month follow-up study)

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Summary

The diagnosis of pseudohypoparathyroidism with osteitis fibrosa was made in a 51-year-old woman on the basis of hypocalcaemia, elevated plasma PTH (1–84) and blunted cAMP response to hPTH infusion. Radiologically, widespread signs of hyperparathyroidism were observed and quantitative histomorphometry confirmed the increased bone cellular turnover. Treatment with calcitriol (1,25 dihydroxyvitamin D3) induced a dramatic improvement of bone lesions. During treatment PTH (1–84) normalized with high dosage of calcitriol in spite of low or subnormal levels of serum calcium, and subsequently increased for each reduction of calcitriol dosage despite normal calcium levels. Our observations support a major and direct effect of 1,25 dihydroxyvitamin D3 on the regulation of parathyroid secretion of parathyroids glands.

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Authors and Affiliations

  1. Department of Rheumatology, CHU Angers, 49 033, Angers Cédex 01, France

    P. Giraud, M. Audran M.D. & C. Bregeon

  2. Department of Internal Medicine and Endocirinology, CHU Angers, 49 033, Angers Cédex 01, France

    V. Rohmer & J. -C. Bigorgne

  3. Department of Nuclear Medicine, CHU Angers, 49 033, Angers Cédex 01, France

    P. Jallet

  4. Department of Histology, CHU Angers, 49 033, Angers Cédex 01, France

    M. F. Basle

Authors
  1. P. Giraud
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  2. M. Audran M.D.
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  3. V. Rohmer
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  4. P. Jallet
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  5. M. F. Basle
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  6. C. Bregeon
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  7. J. -C. Bigorgne
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Giraud, P., Audran, M., Rohmer, V. et al. Direct effect of calcitriol on the regulation of parathyroid hormone secretion in a case of pseudo-hypoparathyroidism (a 24-month follow-up study). Clin Rheumatol 14, 287–291 (1995). https://doi.org/10.1007/BF02208341

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  • DOI: https://doi.org/10.1007/BF02208341

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