Skip to main content
Log in

Gastrointestinal involvement in Langerhans' cell histiocytosis (Histiocytosis X): A clinical report of three cases

  • Hematology/Oncology
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

The gastrointestinal tract may be involved in Langerhans' cell histiocytosis, either as part of a generalized disease or as a separate primary entitiy. Three patients with gastrointestinal involvement are described. One patient presented with a history of prolonged vomiting and diarrhoea with blood and mucus. In this case the diagnosis was based on colonic biopsies. Gastrointestinal tract involvement and its investigation in the diagnosis of Langerhans' cell histiocytosis are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Broadbent V, Davies EG, Heaf D, Pincott JR, Pritchard J, Levinsky RJ, Atherton DM, Tucker, S (1984) Spontaneous remission of multi-system histiocytosis X. Lancet, I:253–254

    Google Scholar 

  2. Corbeel L, Eggermont E, Desmyter J, Surmont I, De Vos R, De Wolf-Peeters C, Cobbaert C, Eykens A (1988) Spontaneous healing of Langerhans cell histiocytosis (histiocytosis X). Eur J Pediatr 148:32–33

    Google Scholar 

  3. Deprettere A, Aelvoet G, Acker KJ van, Dockx P (1983) Intractable diarrhea in histiocytosis X. Helv Paediatr Acta 38:291–294

    Google Scholar 

  4. Favara EF, Jaffe R (1987) Pathology of Langerhans cell histiocytosis. Hematol Oncol North Am 1:75–97

    Google Scholar 

  5. Grundy P, Ellis R (1986) Histiocytosis X: a review of the etiology, pathology, staging and therapy. Med Pediatr Oncol 14:664–671

    Google Scholar 

  6. Hyams JS, Haswell JE, Gerber MA, Berman MM (1985) Colonic ulceration in histiocytosis X. J Pediatr Gastroenterol Nutr 4:286–290

    Google Scholar 

  7. Idlibi O, Hamoudi AB (1984) Primary histiocytosis X of bowel. Pediatr Pathol 2:492

    Google Scholar 

  8. Keeling JW, Harries JT (1973) Intestinal malabsorption in infants with histiocytosis X. Arch Dis Child 48:350–354

    Google Scholar 

  9. Komp DM, Herson J, Starling KA, Viette TJ, Hvizdala E (1981) A staging system for histiocytosis X: a Southwest Oncology Group Study. Cancer 47:798–800

    Google Scholar 

  10. Lahey ME (1962) Prognosis in reticuloendotheliosis in children. J Pediatr 60:664–671

    Google Scholar 

  11. Lahey ME (1975) Histiocytosis X: an analysis of prognostic factors. J Pediatr 87:184–189

    Google Scholar 

  12. Lichtenstein L (1953) Histiocytosis X; integration of eosinophilic granuloma of bone, “Letterer-Siwe Disease”, and “Schüller-Christian Disease” as related manifestations of a single nosologic entity. Arch Pathol 56:84–102

    Google Scholar 

  13. Nesbit ME (1986) Current concepts and treatment of histiocytosis X (Langerhans' cell histiocytosis). In: Voûte PA, Barrett A, Bloom HJG, Lemerle J, Neidhardt MK (eds) Cancer in children, 2nd edn. Springer, Berlin Heidelberg New York 1:176–184

    Google Scholar 

  14. Nezelof C, Basset F, Rousseau MF (1973) Histiocytosis X; histogenetic arguments of a Langerhans cell origin. Biomedicine 18:365–371

    Google Scholar 

  15. Nezelof C, Frileux-Herbet F, Cronier-Sachot J (1979) Disseminated histiocytosis X: analysis of prognostic factors based on a retrospective study of 50 cases. Cancer 44:1824–1838

    Google Scholar 

  16. Nihei K, Terashima K, Aoyama K, Imai Y, Sato H (1983) Benign histiocytosis X of stomach. Acta Pathol Jpn 33:577–588

    Google Scholar 

  17. Risdall RJ, Dehner LP, Duray P, Kobrinsky N, Robison L, Nesbit ME (1983) Histiocytosis X (Langerhans' cell histiocytosis). Arch Pathol Lab Med 107:59–63

    Google Scholar 

  18. Sutphen JL, Fechner RE (1986) Chronic gastroenteritis in an patient with histiocytosis X. J Pediatr Gastroenterol Nutr 5:324–328

    Google Scholar 

  19. Tamura T, Umetsu M, Motoya H, Yokoyama S (1980) Congenital Letterer-Siwe disease associated with protein losing enteropathy. Eur J Pediatr 135:77–80

    Google Scholar 

  20. Waldmann TA (1966) Protein-losing enteropathy. Gastroenterology 50:422–443

    Google Scholar 

  21. The Writing Group of the Histiocyte Society (1987) Histiocytosis syndromes in children. Lancet I:208–209

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Egeler, R.M., Schipper, M.E.I. & Heymans, H.S.A. Gastrointestinal involvement in Langerhans' cell histiocytosis (Histiocytosis X): A clinical report of three cases. Eur J Pediatr 149, 325–329 (1990). https://doi.org/10.1007/BF02171558

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02171558

Key words

Navigation